HOXB13, a Target of DNMT3B, Is Methylated at an Upstream CpG Island, and Functions as a Tumor Suppressor in Primary Colorectal Tumors

BACKGROUND: A hallmark of cancer cells is hypermethylation of CpG islands (CGIs), which probably arises from upregulation of one or more DNA methyltransferases. The purpose of this study was to identify the targets of DNMT3B, an essential DNA methyltransferase in mammals, in colon cancer. METHODOLOG...

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Detalles Bibliográficos
Autores principales: Ghoshal, Kalpana, Motiwala, Tasneem, Claus, Rainer, Yan, Pearlly, Kutay, Huban, Datta, Jharna, Majumder, Sarmila, Bai, Shoumei, Majumder, Arnab, Huang, Tim, Plass, Christoph, Jacob, Samson T.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861599/
https://www.ncbi.nlm.nih.gov/pubmed/20454457
http://dx.doi.org/10.1371/journal.pone.0010338

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