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TNF-α and neuropathic pain - a review
Tumor necrosis factor alpha (TNF-α) was discovered more than a century ago, and its known roles have extended from within the immune system to include a neuro-inflammatory domain in the nervous system. Neuropathic pain is a recognized type of pathological pain where nociceptive responses persist bey...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861665/ https://www.ncbi.nlm.nih.gov/pubmed/20398373 http://dx.doi.org/10.1186/1742-2094-7-27 |
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author | Leung, Lawrence Cahill, Catherine M |
author_facet | Leung, Lawrence Cahill, Catherine M |
author_sort | Leung, Lawrence |
collection | PubMed |
description | Tumor necrosis factor alpha (TNF-α) was discovered more than a century ago, and its known roles have extended from within the immune system to include a neuro-inflammatory domain in the nervous system. Neuropathic pain is a recognized type of pathological pain where nociceptive responses persist beyond the resolution of damage to the nerve or its surrounding tissue. Very often, neuropathic pain is disproportionately enhanced in intensity (hyperalgesia) or altered in modality (hyperpathia or allodynia) in relation to the stimuli. At time of this writing, there is as yet no common consensus about the etiology of neuropathic pain - possible mechanisms can be categorized into peripheral sensitization and central sensitization of the nervous system in response to the nociceptive stimuli. Animal models of neuropathic pain based on various types of nerve injuries (peripheral versus spinal nerve, ligation versus chronic constrictive injury) have persistently implicated a pivotal role for TNF-α at both peripheral and central levels of sensitization. Despite a lack of success in clinical trials of anti-TNF-α therapy in alleviating the sciatic type of neuropathic pain, the intricate link of TNF-α with other neuro-inflammatory signaling systems (e.g., chemokines and p38 MAPK) has indeed inspired a systems approach perspective for future drug development in treating neuropathic pain. |
format | Text |
id | pubmed-2861665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28616652010-04-30 TNF-α and neuropathic pain - a review Leung, Lawrence Cahill, Catherine M J Neuroinflammation Review Tumor necrosis factor alpha (TNF-α) was discovered more than a century ago, and its known roles have extended from within the immune system to include a neuro-inflammatory domain in the nervous system. Neuropathic pain is a recognized type of pathological pain where nociceptive responses persist beyond the resolution of damage to the nerve or its surrounding tissue. Very often, neuropathic pain is disproportionately enhanced in intensity (hyperalgesia) or altered in modality (hyperpathia or allodynia) in relation to the stimuli. At time of this writing, there is as yet no common consensus about the etiology of neuropathic pain - possible mechanisms can be categorized into peripheral sensitization and central sensitization of the nervous system in response to the nociceptive stimuli. Animal models of neuropathic pain based on various types of nerve injuries (peripheral versus spinal nerve, ligation versus chronic constrictive injury) have persistently implicated a pivotal role for TNF-α at both peripheral and central levels of sensitization. Despite a lack of success in clinical trials of anti-TNF-α therapy in alleviating the sciatic type of neuropathic pain, the intricate link of TNF-α with other neuro-inflammatory signaling systems (e.g., chemokines and p38 MAPK) has indeed inspired a systems approach perspective for future drug development in treating neuropathic pain. BioMed Central 2010-04-16 /pmc/articles/PMC2861665/ /pubmed/20398373 http://dx.doi.org/10.1186/1742-2094-7-27 Text en Copyright ©2010 Leung and Cahill; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Leung, Lawrence Cahill, Catherine M TNF-α and neuropathic pain - a review |
title | TNF-α and neuropathic pain - a review |
title_full | TNF-α and neuropathic pain - a review |
title_fullStr | TNF-α and neuropathic pain - a review |
title_full_unstemmed | TNF-α and neuropathic pain - a review |
title_short | TNF-α and neuropathic pain - a review |
title_sort | tnf-α and neuropathic pain - a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861665/ https://www.ncbi.nlm.nih.gov/pubmed/20398373 http://dx.doi.org/10.1186/1742-2094-7-27 |
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