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Multilayered Mechanism of CD4 Downregulation by HIV-1 Vpu Involving Distinct ER Retention and ERAD Targeting Steps

A key function of the Vpu protein of HIV-1 is the targeting of newly-synthesized CD4 for proteasomal degradation. This function has been proposed to occur by a mechanism that is fundamentally distinct from the cellular ER-associated degradation (ERAD) pathway. However, using a combination of genetic...

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Detalles Bibliográficos
Autores principales:	Magadán, Javier G., Pérez-Victoria, F. Javier, Sougrat, Rachid, Ye, Yihong, Strebel, Klaus, Bonifacino, Juan S.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861688/ https://www.ncbi.nlm.nih.gov/pubmed/20442859 http://dx.doi.org/10.1371/journal.ppat.1000869

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