Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway

Hypoxic microenvironment supports cancer stem cell survival, causes poor response to anticancer therapy and tumor recurrence. Inhibition of Notch-1 signaling in adenocarcinoma of the lung (ACL) cells causes apoptosis specifically under hypoxia. Here we found that Akt-1 activation is a key mediator o...

Descripción completa

Detalles Bibliográficos
Autores principales: Eliasz, Sandra, Liang, Shuang, Chen, Yuanbin, De Marco, Melissa A., Machek, Ovidiu, Skucha, Sylvia, Miele, Lucio, Bocchetta, Maurizio
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861728/
https://www.ncbi.nlm.nih.gov/pubmed/20154720
http://dx.doi.org/10.1038/onc.2010.7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861728/
https://www.ncbi.nlm.nih.gov/pubmed/20154720
http://dx.doi.org/10.1038/onc.2010.7

Ejemplares similares