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Intracameral vancomycin following cataract surgery: An eleven-year study

AIM: To compare the incidences of endophthalmitis after cataract operations before and after introduction of intracameral vancomycin at the end of surgery. METHODS: A retrospective analysis was performed of presumed infectious endophthalmitis after cataract surgery from January 1, 1998 to December 3...

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Autores principales: Anijeet, Deepa R, Palimar, Prasad, Peckar, Clive O
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861939/
https://www.ncbi.nlm.nih.gov/pubmed/20463800
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author Anijeet, Deepa R
Palimar, Prasad
Peckar, Clive O
author_facet Anijeet, Deepa R
Palimar, Prasad
Peckar, Clive O
author_sort Anijeet, Deepa R
collection PubMed
description AIM: To compare the incidences of endophthalmitis after cataract operations before and after introduction of intracameral vancomycin at the end of surgery. METHODS: A retrospective analysis was performed of presumed infectious endophthalmitis after cataract surgery from January 1, 1998 to December 31, 2008. From January 2001, the practice of using intracameral vancomycin at the end of cataract surgery was introduced. The period before introduction of intracameral vancomycin is considered as period A and that after as period B. The incidences of presumed or culture-proven endophthalmitis during periods A and B were compared. RESULTS: A total of 16,606 cataract surgeries were performed during the study period. The incidence of endophthalmitis per 1000 cataract surgeries was 3.0 during period A and 0.08 during period B. This reduction was statistically significantly (Chi-squared test 36.6, P value < 0.0001). The relative risk of developing endophthalmitis without intracameral vancomycin prophylaxis was 38. The absolute risk reduction was 292 cases of endophthalmitis per 100,000 cataract surgeries. CONCLUSIONS: Intracameral vancomycin significantly reduced the incidence of postoperative endophthalmitis after cataract surgery. There is a universal need to adopt this mode of microbial prophylaxis to reduce the burden of endophthalmitis after cataract surgery.
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spelling pubmed-28619392010-05-12 Intracameral vancomycin following cataract surgery: An eleven-year study Anijeet, Deepa R Palimar, Prasad Peckar, Clive O Clin Ophthalmol Original Research AIM: To compare the incidences of endophthalmitis after cataract operations before and after introduction of intracameral vancomycin at the end of surgery. METHODS: A retrospective analysis was performed of presumed infectious endophthalmitis after cataract surgery from January 1, 1998 to December 31, 2008. From January 2001, the practice of using intracameral vancomycin at the end of cataract surgery was introduced. The period before introduction of intracameral vancomycin is considered as period A and that after as period B. The incidences of presumed or culture-proven endophthalmitis during periods A and B were compared. RESULTS: A total of 16,606 cataract surgeries were performed during the study period. The incidence of endophthalmitis per 1000 cataract surgeries was 3.0 during period A and 0.08 during period B. This reduction was statistically significantly (Chi-squared test 36.6, P value < 0.0001). The relative risk of developing endophthalmitis without intracameral vancomycin prophylaxis was 38. The absolute risk reduction was 292 cases of endophthalmitis per 100,000 cataract surgeries. CONCLUSIONS: Intracameral vancomycin significantly reduced the incidence of postoperative endophthalmitis after cataract surgery. There is a universal need to adopt this mode of microbial prophylaxis to reduce the burden of endophthalmitis after cataract surgery. Dove Medical Press 2010 2010-04-26 /pmc/articles/PMC2861939/ /pubmed/20463800 Text en © 2010 Anijeet et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Anijeet, Deepa R
Palimar, Prasad
Peckar, Clive O
Intracameral vancomycin following cataract surgery: An eleven-year study
title Intracameral vancomycin following cataract surgery: An eleven-year study
title_full Intracameral vancomycin following cataract surgery: An eleven-year study
title_fullStr Intracameral vancomycin following cataract surgery: An eleven-year study
title_full_unstemmed Intracameral vancomycin following cataract surgery: An eleven-year study
title_short Intracameral vancomycin following cataract surgery: An eleven-year study
title_sort intracameral vancomycin following cataract surgery: an eleven-year study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861939/
https://www.ncbi.nlm.nih.gov/pubmed/20463800
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