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Recurrence of hyperemesis gravidarum across generations: population based cohort study
Objective To estimate the risk of hyperemesis gravidarum (hyperemesis) according to whether the daughters and sons under study were born after pregnancies complicated by hyperemesis. Design Population based cohort study. Setting Registry data from Norway. Participants Linked generational data from t...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BMJ Publishing Group Ltd.
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862151/ https://www.ncbi.nlm.nih.gov/pubmed/21030362 http://dx.doi.org/10.1136/bmj.c2050 |
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author | Vikanes, Åse Skjærven, Rolv Grjibovski, Andrej M Gunnes, Nina Vangen, Siri Magnus, Per |
author_facet | Vikanes, Åse Skjærven, Rolv Grjibovski, Andrej M Gunnes, Nina Vangen, Siri Magnus, Per |
author_sort | Vikanes, Åse |
collection | PubMed |
description | Objective To estimate the risk of hyperemesis gravidarum (hyperemesis) according to whether the daughters and sons under study were born after pregnancies complicated by hyperemesis. Design Population based cohort study. Setting Registry data from Norway. Participants Linked generational data from the medical birth registry of Norway (1967-2006): 544 087 units of mother and childbearing daughter and 399 777 units of mother and child producing son. Main outcome measure Hyperemesis in daughters in mother and childbearing daughter units and hyperemesis in female partners of sons in mother and child producing son units. Results Daughters who were born after a pregnancy complicated by hyperemesis had a 3% risk of having hyperemesis in their own pregnancy, while women who were born after an unaffected pregnancy had a risk of 1.1% (unadjusted odds ratio 2.9, 95% confidence interval 2.4 to 3.6). Female partners of sons who were born after pregnancies complicated by hyperemesis had a risk of 1.2% (1.0, 0.7 to 1.6). Daughters born after a pregnancy not complicated by hyperemesis had an increased risk of the condition if the mother had hyperemesis in a previous or subsequent pregnancy (3.2 (1.6 to 6.4) if hyperemesis had occurred in one of the mother’s previous pregnancies and 3.7 (1.5 to 9.1) if it had occurred in a later pregnancy). Adjustment for maternal age at childbirth, period of birth, and parity did not change the estimates. Restrictions to firstborns did not influence the results. Conclusions Hyperemesis gravidarum is more strongly influenced by the maternal genotype than the fetal genotype, though environmental influences along the maternal line cannot be excluded as contributing factors. |
format | Text |
id | pubmed-2862151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BMJ Publishing Group Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-28621512010-05-18 Recurrence of hyperemesis gravidarum across generations: population based cohort study Vikanes, Åse Skjærven, Rolv Grjibovski, Andrej M Gunnes, Nina Vangen, Siri Magnus, Per BMJ Research Objective To estimate the risk of hyperemesis gravidarum (hyperemesis) according to whether the daughters and sons under study were born after pregnancies complicated by hyperemesis. Design Population based cohort study. Setting Registry data from Norway. Participants Linked generational data from the medical birth registry of Norway (1967-2006): 544 087 units of mother and childbearing daughter and 399 777 units of mother and child producing son. Main outcome measure Hyperemesis in daughters in mother and childbearing daughter units and hyperemesis in female partners of sons in mother and child producing son units. Results Daughters who were born after a pregnancy complicated by hyperemesis had a 3% risk of having hyperemesis in their own pregnancy, while women who were born after an unaffected pregnancy had a risk of 1.1% (unadjusted odds ratio 2.9, 95% confidence interval 2.4 to 3.6). Female partners of sons who were born after pregnancies complicated by hyperemesis had a risk of 1.2% (1.0, 0.7 to 1.6). Daughters born after a pregnancy not complicated by hyperemesis had an increased risk of the condition if the mother had hyperemesis in a previous or subsequent pregnancy (3.2 (1.6 to 6.4) if hyperemesis had occurred in one of the mother’s previous pregnancies and 3.7 (1.5 to 9.1) if it had occurred in a later pregnancy). Adjustment for maternal age at childbirth, period of birth, and parity did not change the estimates. Restrictions to firstborns did not influence the results. Conclusions Hyperemesis gravidarum is more strongly influenced by the maternal genotype than the fetal genotype, though environmental influences along the maternal line cannot be excluded as contributing factors. BMJ Publishing Group Ltd. 2010-04-29 /pmc/articles/PMC2862151/ /pubmed/21030362 http://dx.doi.org/10.1136/bmj.c2050 Text en © Vikanes et al 2010 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode. |
spellingShingle | Research Vikanes, Åse Skjærven, Rolv Grjibovski, Andrej M Gunnes, Nina Vangen, Siri Magnus, Per Recurrence of hyperemesis gravidarum across generations: population based cohort study |
title | Recurrence of hyperemesis gravidarum across generations: population based cohort study |
title_full | Recurrence of hyperemesis gravidarum across generations: population based cohort study |
title_fullStr | Recurrence of hyperemesis gravidarum across generations: population based cohort study |
title_full_unstemmed | Recurrence of hyperemesis gravidarum across generations: population based cohort study |
title_short | Recurrence of hyperemesis gravidarum across generations: population based cohort study |
title_sort | recurrence of hyperemesis gravidarum across generations: population based cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862151/ https://www.ncbi.nlm.nih.gov/pubmed/21030362 http://dx.doi.org/10.1136/bmj.c2050 |
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