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Recurrence of hyperemesis gravidarum across generations: population based cohort study

Objective To estimate the risk of hyperemesis gravidarum (hyperemesis) according to whether the daughters and sons under study were born after pregnancies complicated by hyperemesis. Design Population based cohort study. Setting Registry data from Norway. Participants Linked generational data from t...

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Autores principales: Vikanes, Åse, Skjærven, Rolv, Grjibovski, Andrej M, Gunnes, Nina, Vangen, Siri, Magnus, Per
Formato: Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862151/
https://www.ncbi.nlm.nih.gov/pubmed/21030362
http://dx.doi.org/10.1136/bmj.c2050
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author Vikanes, Åse
Skjærven, Rolv
Grjibovski, Andrej M
Gunnes, Nina
Vangen, Siri
Magnus, Per
author_facet Vikanes, Åse
Skjærven, Rolv
Grjibovski, Andrej M
Gunnes, Nina
Vangen, Siri
Magnus, Per
author_sort Vikanes, Åse
collection PubMed
description Objective To estimate the risk of hyperemesis gravidarum (hyperemesis) according to whether the daughters and sons under study were born after pregnancies complicated by hyperemesis. Design Population based cohort study. Setting Registry data from Norway. Participants Linked generational data from the medical birth registry of Norway (1967-2006): 544 087 units of mother and childbearing daughter and 399 777 units of mother and child producing son. Main outcome measure Hyperemesis in daughters in mother and childbearing daughter units and hyperemesis in female partners of sons in mother and child producing son units. Results Daughters who were born after a pregnancy complicated by hyperemesis had a 3% risk of having hyperemesis in their own pregnancy, while women who were born after an unaffected pregnancy had a risk of 1.1% (unadjusted odds ratio 2.9, 95% confidence interval 2.4 to 3.6). Female partners of sons who were born after pregnancies complicated by hyperemesis had a risk of 1.2% (1.0, 0.7 to 1.6). Daughters born after a pregnancy not complicated by hyperemesis had an increased risk of the condition if the mother had hyperemesis in a previous or subsequent pregnancy (3.2 (1.6 to 6.4) if hyperemesis had occurred in one of the mother’s previous pregnancies and 3.7 (1.5 to 9.1) if it had occurred in a later pregnancy). Adjustment for maternal age at childbirth, period of birth, and parity did not change the estimates. Restrictions to firstborns did not influence the results. Conclusions Hyperemesis gravidarum is more strongly influenced by the maternal genotype than the fetal genotype, though environmental influences along the maternal line cannot be excluded as contributing factors.
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spelling pubmed-28621512010-05-18 Recurrence of hyperemesis gravidarum across generations: population based cohort study Vikanes, Åse Skjærven, Rolv Grjibovski, Andrej M Gunnes, Nina Vangen, Siri Magnus, Per BMJ Research Objective To estimate the risk of hyperemesis gravidarum (hyperemesis) according to whether the daughters and sons under study were born after pregnancies complicated by hyperemesis. Design Population based cohort study. Setting Registry data from Norway. Participants Linked generational data from the medical birth registry of Norway (1967-2006): 544 087 units of mother and childbearing daughter and 399 777 units of mother and child producing son. Main outcome measure Hyperemesis in daughters in mother and childbearing daughter units and hyperemesis in female partners of sons in mother and child producing son units. Results Daughters who were born after a pregnancy complicated by hyperemesis had a 3% risk of having hyperemesis in their own pregnancy, while women who were born after an unaffected pregnancy had a risk of 1.1% (unadjusted odds ratio 2.9, 95% confidence interval 2.4 to 3.6). Female partners of sons who were born after pregnancies complicated by hyperemesis had a risk of 1.2% (1.0, 0.7 to 1.6). Daughters born after a pregnancy not complicated by hyperemesis had an increased risk of the condition if the mother had hyperemesis in a previous or subsequent pregnancy (3.2 (1.6 to 6.4) if hyperemesis had occurred in one of the mother’s previous pregnancies and 3.7 (1.5 to 9.1) if it had occurred in a later pregnancy). Adjustment for maternal age at childbirth, period of birth, and parity did not change the estimates. Restrictions to firstborns did not influence the results. Conclusions Hyperemesis gravidarum is more strongly influenced by the maternal genotype than the fetal genotype, though environmental influences along the maternal line cannot be excluded as contributing factors. BMJ Publishing Group Ltd. 2010-04-29 /pmc/articles/PMC2862151/ /pubmed/21030362 http://dx.doi.org/10.1136/bmj.c2050 Text en © Vikanes et al 2010 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
spellingShingle Research
Vikanes, Åse
Skjærven, Rolv
Grjibovski, Andrej M
Gunnes, Nina
Vangen, Siri
Magnus, Per
Recurrence of hyperemesis gravidarum across generations: population based cohort study
title Recurrence of hyperemesis gravidarum across generations: population based cohort study
title_full Recurrence of hyperemesis gravidarum across generations: population based cohort study
title_fullStr Recurrence of hyperemesis gravidarum across generations: population based cohort study
title_full_unstemmed Recurrence of hyperemesis gravidarum across generations: population based cohort study
title_short Recurrence of hyperemesis gravidarum across generations: population based cohort study
title_sort recurrence of hyperemesis gravidarum across generations: population based cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862151/
https://www.ncbi.nlm.nih.gov/pubmed/21030362
http://dx.doi.org/10.1136/bmj.c2050
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