Cargando…
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (N=10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in thirteen replication studies (N=27,591). Rs900400 near LEKR1 and CCNL1 (P=2×10(−35)), and rs9883...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862164/ https://www.ncbi.nlm.nih.gov/pubmed/20372150 http://dx.doi.org/10.1038/ng.567 |
| _version_ | 1782180696570200064 |
|---|---|
| author | Freathy, Rachel M Mook-Kanamori, Dennis O Sovio, Ulla Prokopenko, Inga Timpson, Nicholas J Berry, Diane J Warrington, Nicole M Widen, Elisabeth Hottenga, Jouke Jan Kaakinen, Marika Lange, Leslie A Bradfield, Jonathan P Kerkhof, Marjan Marsh, Julie A Mägi, Reedik Chen, Chih-Mei Lyon, Helen N Kirin, Mirna Adair, Linda S Aulchenko, Yurii S Bennett, Amanda J Borja, Judith B Bouatia-Naji, Nabila Charoen, Pimphen Coin, Lachlan J M Cousminer, Diana L de Geus, Eco J. C. Deloukas, Panos Elliott, Paul Evans, David M Froguel, Philippe Glaser, Beate Groves, Christopher J Hartikainen, Anna-Liisa Hassanali, Neelam Hirschhorn, Joel N Hofman, Albert Holly, Jeff M P Hyppönen, Elina Kanoni, Stavroula Knight, Bridget A Laitinen, Jaana Lindgren, Cecilia M McArdle, Wendy L O'Reilly, Paul F Pennell, Craig E Postma, Dirkje S Pouta, Anneli Ramasamy, Adaikalavan Rayner, Nigel W Ring, Susan M Rivadeneira, Fernando Shields, Beverley M Strachan, David P Surakka, Ida Taanila, Anja Tiesler, Carla Uitterlinden, Andre G van Duijn, Cornelia M Wijga, Alet H Willemsen, Gonneke Zhang, Haitao Zhao, Jianhua Wilson, James F Steegers, Eric A P Hattersley, Andrew T Eriksson, Johan G Peltonen, Leena Mohlke, Karen L Grant, Struan F A Hakonarson, Hakon Koppelman, Gerard H Dedoussis, George V Heinrich, Joachim Gillman, Matthew W Palmer, Lyle J Frayling, Timothy M Boomsma, Dorret I Smith, George Davey Power, Chris Jaddoe, Vincent W V Jarvelin, Marjo-Riitta McCarthy, Mark I |
| author_facet | Freathy, Rachel M Mook-Kanamori, Dennis O Sovio, Ulla Prokopenko, Inga Timpson, Nicholas J Berry, Diane J Warrington, Nicole M Widen, Elisabeth Hottenga, Jouke Jan Kaakinen, Marika Lange, Leslie A Bradfield, Jonathan P Kerkhof, Marjan Marsh, Julie A Mägi, Reedik Chen, Chih-Mei Lyon, Helen N Kirin, Mirna Adair, Linda S Aulchenko, Yurii S Bennett, Amanda J Borja, Judith B Bouatia-Naji, Nabila Charoen, Pimphen Coin, Lachlan J M Cousminer, Diana L de Geus, Eco J. C. Deloukas, Panos Elliott, Paul Evans, David M Froguel, Philippe Glaser, Beate Groves, Christopher J Hartikainen, Anna-Liisa Hassanali, Neelam Hirschhorn, Joel N Hofman, Albert Holly, Jeff M P Hyppönen, Elina Kanoni, Stavroula Knight, Bridget A Laitinen, Jaana Lindgren, Cecilia M McArdle, Wendy L O'Reilly, Paul F Pennell, Craig E Postma, Dirkje S Pouta, Anneli Ramasamy, Adaikalavan Rayner, Nigel W Ring, Susan M Rivadeneira, Fernando Shields, Beverley M Strachan, David P Surakka, Ida Taanila, Anja Tiesler, Carla Uitterlinden, Andre G van Duijn, Cornelia M Wijga, Alet H Willemsen, Gonneke Zhang, Haitao Zhao, Jianhua Wilson, James F Steegers, Eric A P Hattersley, Andrew T Eriksson, Johan G Peltonen, Leena Mohlke, Karen L Grant, Struan F A Hakonarson, Hakon Koppelman, Gerard H Dedoussis, George V Heinrich, Joachim Gillman, Matthew W Palmer, Lyle J Frayling, Timothy M Boomsma, Dorret I Smith, George Davey Power, Chris Jaddoe, Vincent W V Jarvelin, Marjo-Riitta McCarthy, Mark I |
| author_sort | Freathy, Rachel M |
| collection | PubMed |
| description | To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (N=10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in thirteen replication studies (N=27,591). Rs900400 near LEKR1 and CCNL1 (P=2×10(−35)), and rs9883204 in ADCY5 (P=7×10(−15)) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and type 2 diabetes susceptibility,1 providing evidence that the well described association between lower birth weight and subsequent type 2 diabetes2,3 has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, the 9% of Europeans with 4 birth weight-lowering alleles were, on average, 113g (95%CI 89-137g) lighter at birth than the 24% with 0 or 1 allele (P(trend)=7×10(−30)). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy.4 |
| format | Text |
| id | pubmed-2862164 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-28621642010-11-01 Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight Freathy, Rachel M Mook-Kanamori, Dennis O Sovio, Ulla Prokopenko, Inga Timpson, Nicholas J Berry, Diane J Warrington, Nicole M Widen, Elisabeth Hottenga, Jouke Jan Kaakinen, Marika Lange, Leslie A Bradfield, Jonathan P Kerkhof, Marjan Marsh, Julie A Mägi, Reedik Chen, Chih-Mei Lyon, Helen N Kirin, Mirna Adair, Linda S Aulchenko, Yurii S Bennett, Amanda J Borja, Judith B Bouatia-Naji, Nabila Charoen, Pimphen Coin, Lachlan J M Cousminer, Diana L de Geus, Eco J. C. Deloukas, Panos Elliott, Paul Evans, David M Froguel, Philippe Glaser, Beate Groves, Christopher J Hartikainen, Anna-Liisa Hassanali, Neelam Hirschhorn, Joel N Hofman, Albert Holly, Jeff M P Hyppönen, Elina Kanoni, Stavroula Knight, Bridget A Laitinen, Jaana Lindgren, Cecilia M McArdle, Wendy L O'Reilly, Paul F Pennell, Craig E Postma, Dirkje S Pouta, Anneli Ramasamy, Adaikalavan Rayner, Nigel W Ring, Susan M Rivadeneira, Fernando Shields, Beverley M Strachan, David P Surakka, Ida Taanila, Anja Tiesler, Carla Uitterlinden, Andre G van Duijn, Cornelia M Wijga, Alet H Willemsen, Gonneke Zhang, Haitao Zhao, Jianhua Wilson, James F Steegers, Eric A P Hattersley, Andrew T Eriksson, Johan G Peltonen, Leena Mohlke, Karen L Grant, Struan F A Hakonarson, Hakon Koppelman, Gerard H Dedoussis, George V Heinrich, Joachim Gillman, Matthew W Palmer, Lyle J Frayling, Timothy M Boomsma, Dorret I Smith, George Davey Power, Chris Jaddoe, Vincent W V Jarvelin, Marjo-Riitta McCarthy, Mark I Nat Genet Article To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (N=10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in thirteen replication studies (N=27,591). Rs900400 near LEKR1 and CCNL1 (P=2×10(−35)), and rs9883204 in ADCY5 (P=7×10(−15)) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and type 2 diabetes susceptibility,1 providing evidence that the well described association between lower birth weight and subsequent type 2 diabetes2,3 has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, the 9% of Europeans with 4 birth weight-lowering alleles were, on average, 113g (95%CI 89-137g) lighter at birth than the 24% with 0 or 1 allele (P(trend)=7×10(−30)). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy.4 2010-04-06 2010-05 /pmc/articles/PMC2862164/ /pubmed/20372150 http://dx.doi.org/10.1038/ng.567 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Freathy, Rachel M Mook-Kanamori, Dennis O Sovio, Ulla Prokopenko, Inga Timpson, Nicholas J Berry, Diane J Warrington, Nicole M Widen, Elisabeth Hottenga, Jouke Jan Kaakinen, Marika Lange, Leslie A Bradfield, Jonathan P Kerkhof, Marjan Marsh, Julie A Mägi, Reedik Chen, Chih-Mei Lyon, Helen N Kirin, Mirna Adair, Linda S Aulchenko, Yurii S Bennett, Amanda J Borja, Judith B Bouatia-Naji, Nabila Charoen, Pimphen Coin, Lachlan J M Cousminer, Diana L de Geus, Eco J. C. Deloukas, Panos Elliott, Paul Evans, David M Froguel, Philippe Glaser, Beate Groves, Christopher J Hartikainen, Anna-Liisa Hassanali, Neelam Hirschhorn, Joel N Hofman, Albert Holly, Jeff M P Hyppönen, Elina Kanoni, Stavroula Knight, Bridget A Laitinen, Jaana Lindgren, Cecilia M McArdle, Wendy L O'Reilly, Paul F Pennell, Craig E Postma, Dirkje S Pouta, Anneli Ramasamy, Adaikalavan Rayner, Nigel W Ring, Susan M Rivadeneira, Fernando Shields, Beverley M Strachan, David P Surakka, Ida Taanila, Anja Tiesler, Carla Uitterlinden, Andre G van Duijn, Cornelia M Wijga, Alet H Willemsen, Gonneke Zhang, Haitao Zhao, Jianhua Wilson, James F Steegers, Eric A P Hattersley, Andrew T Eriksson, Johan G Peltonen, Leena Mohlke, Karen L Grant, Struan F A Hakonarson, Hakon Koppelman, Gerard H Dedoussis, George V Heinrich, Joachim Gillman, Matthew W Palmer, Lyle J Frayling, Timothy M Boomsma, Dorret I Smith, George Davey Power, Chris Jaddoe, Vincent W V Jarvelin, Marjo-Riitta McCarthy, Mark I Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight |
| title | Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight |
| title_full | Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight |
| title_fullStr | Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight |
| title_full_unstemmed | Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight |
| title_short | Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight |
| title_sort | variants in adcy5 and near ccnl1 are associated with fetal growth and birth weight |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862164/ https://www.ncbi.nlm.nih.gov/pubmed/20372150 http://dx.doi.org/10.1038/ng.567 |
| work_keys_str_mv | AT freathyrachelm variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT mookkanamoridenniso variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT sovioulla variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT prokopenkoinga variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT timpsonnicholasj variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT berrydianej variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT warringtonnicolem variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT widenelisabeth variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT hottengajoukejan variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT kaakinenmarika variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT langelesliea variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT bradfieldjonathanp variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT kerkhofmarjan variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT marshjuliea variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT magireedik variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT chenchihmei variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT lyonhelenn variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT kirinmirna variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT adairlindas variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT aulchenkoyuriis variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT bennettamandaj variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT borjajudithb variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT bouatianajinabila variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT charoenpimphen variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT coinlachlanjm variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT cousminerdianal variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT degeusecojc variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT deloukaspanos variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT elliottpaul variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT evansdavidm variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT froguelphilippe variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT glaserbeate variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT groveschristopherj variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT hartikainenannaliisa variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT hassanalineelam variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT hirschhornjoeln variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT hofmanalbert variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT hollyjeffmp variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT hypponenelina variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT kanonistavroula variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT knightbridgeta variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT laitinenjaana variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT lindgrenceciliam variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT mcardlewendyl variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT oreillypaulf variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT pennellcraige variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT postmadirkjes variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT poutaanneli variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT ramasamyadaikalavan variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT raynernigelw variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT ringsusanm variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT rivadeneirafernando variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT shieldsbeverleym variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT strachandavidp variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT surakkaida variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT taanilaanja variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT tieslercarla variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT uitterlindenandreg variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT vanduijncorneliam variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT wijgaaleth variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT willemsengonneke variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT zhanghaitao variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT zhaojianhua variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT wilsonjamesf variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT steegersericap variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT hattersleyandrewt variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT erikssonjohang variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT peltonenleena variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT mohlkekarenl variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT grantstruanfa variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT hakonarsonhakon variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT koppelmangerardh variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT dedoussisgeorgev variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT heinrichjoachim variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT gillmanmattheww variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT palmerlylej variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT fraylingtimothym variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT boomsmadorreti variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT smithgeorgedavey variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT powerchris variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT jaddoevincentwv variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT jarvelinmarjoriitta variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight AT mccarthymarki variantsinadcy5andnearccnl1areassociatedwithfetalgrowthandbirthweight |