Cargando…
Catalytic Therapy of Cancer with Ascorbate and Extracts of Medicinal Herbs
Catalytic therapy (CT) is a cancer treatment modality based on the generation of reactive oxygen species (ROS) using a combination of substrate molecules and a catalyst. The most frequently used substrate/catalyst pair is ascorbate/Co phthalocyanine (PcCo). In the present work, herb extracts contain...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862925/ https://www.ncbi.nlm.nih.gov/pubmed/18955293 http://dx.doi.org/10.1093/ecam/nem159 |
_version_ | 1782180731769847808 |
---|---|
author | Rozanova (Torshina), Nadejda Zhang, Jin Z. Heck, Diane E. |
author_facet | Rozanova (Torshina), Nadejda Zhang, Jin Z. Heck, Diane E. |
author_sort | Rozanova (Torshina), Nadejda |
collection | PubMed |
description | Catalytic therapy (CT) is a cancer treatment modality based on the generation of reactive oxygen species (ROS) using a combination of substrate molecules and a catalyst. The most frequently used substrate/catalyst pair is ascorbate/Co phthalocyanine (PcCo). In the present work, herb extracts containing pigments have been studied as a catalyst in place of PcCo. Extracts from herbs are expected to have efficiency comparable with that of phthalocyanines but as natural products, to exhibit fewer side effects. The present studies demonstrate that a combined use of ascorbate and herbal extracts results in ROS production and a significant decrease in the number of cancer cells after a single in vitro treatment. Treatment with ascorbate in conjunction with extracts prepared from several medicinal herbs stimulated apoptosis and disrupted the cell cycle. The number of cells accumulating in the sub-G0/G1 stage of the cell cycle was increased 2- to 7-fold, and cells in G(2)/M increased 1.5- to 20-fold, indicating that the treatment protocol was highly effective in suppressing DNA synthesis and potentially reflecting DNA damage in the tumor cells. In addition, 20–40% of the cells underwent apoptosis within 24 h of completing treatment. Our results suggest that herbal extracts can function as CT catalysts in the treatment of cancer. |
format | Text |
id | pubmed-2862925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-28629252010-08-02 Catalytic Therapy of Cancer with Ascorbate and Extracts of Medicinal Herbs Rozanova (Torshina), Nadejda Zhang, Jin Z. Heck, Diane E. Evid Based Complement Alternat Med Original Articles - Basic Science Catalytic therapy (CT) is a cancer treatment modality based on the generation of reactive oxygen species (ROS) using a combination of substrate molecules and a catalyst. The most frequently used substrate/catalyst pair is ascorbate/Co phthalocyanine (PcCo). In the present work, herb extracts containing pigments have been studied as a catalyst in place of PcCo. Extracts from herbs are expected to have efficiency comparable with that of phthalocyanines but as natural products, to exhibit fewer side effects. The present studies demonstrate that a combined use of ascorbate and herbal extracts results in ROS production and a significant decrease in the number of cancer cells after a single in vitro treatment. Treatment with ascorbate in conjunction with extracts prepared from several medicinal herbs stimulated apoptosis and disrupted the cell cycle. The number of cells accumulating in the sub-G0/G1 stage of the cell cycle was increased 2- to 7-fold, and cells in G(2)/M increased 1.5- to 20-fold, indicating that the treatment protocol was highly effective in suppressing DNA synthesis and potentially reflecting DNA damage in the tumor cells. In addition, 20–40% of the cells underwent apoptosis within 24 h of completing treatment. Our results suggest that herbal extracts can function as CT catalysts in the treatment of cancer. Oxford University Press 2010-06 2007-12-26 /pmc/articles/PMC2862925/ /pubmed/18955293 http://dx.doi.org/10.1093/ecam/nem159 Text en © 2007 The Author(s). http://creativecommons.org/licenses/by-nc/2.5 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles - Basic Science Rozanova (Torshina), Nadejda Zhang, Jin Z. Heck, Diane E. Catalytic Therapy of Cancer with Ascorbate and Extracts of Medicinal Herbs |
title | Catalytic Therapy of Cancer with Ascorbate and Extracts of Medicinal Herbs |
title_full | Catalytic Therapy of Cancer with Ascorbate and Extracts of Medicinal Herbs |
title_fullStr | Catalytic Therapy of Cancer with Ascorbate and Extracts of Medicinal Herbs |
title_full_unstemmed | Catalytic Therapy of Cancer with Ascorbate and Extracts of Medicinal Herbs |
title_short | Catalytic Therapy of Cancer with Ascorbate and Extracts of Medicinal Herbs |
title_sort | catalytic therapy of cancer with ascorbate and extracts of medicinal herbs |
topic | Original Articles - Basic Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862925/ https://www.ncbi.nlm.nih.gov/pubmed/18955293 http://dx.doi.org/10.1093/ecam/nem159 |
work_keys_str_mv | AT rozanovatorshinanadejda catalytictherapyofcancerwithascorbateandextractsofmedicinalherbs AT zhangjinz catalytictherapyofcancerwithascorbateandextractsofmedicinalherbs AT heckdianee catalytictherapyofcancerwithascorbateandextractsofmedicinalherbs |