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Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

BACKGROUND: Tyrosine kinase 2 (Tyk2), a central component of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, has major effects on innate immunity and inflammation. Mice lacking Tyk2 are resistant to endotoxin shock induced by lipopolysaccharide (LPS), and Tyk2 def...

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Detalles Bibliográficos
Autores principales:	Vogl, Claus, Flatt, Thomas, Fuhrmann, Bernd, Hofmann, Elisabeth, Wallner, Barbara, Stiefvater, Rita, Kovarik, Pavel, Strobl, Birgit, Müller, Mathias
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864243/ https://www.ncbi.nlm.nih.gov/pubmed/20338026 http://dx.doi.org/10.1186/1471-2164-11-199

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