Assessment of Growth Disturbance in Japanese Children with IBD

In Japan, there is as yet no report on growth retardation in children with IBD. We therefore investigated the cause of growth retardation in Japanese children with IBD. We investigated the height, body weight, serum levels of albumin, IGF-I, CRP, and cytokines, and the amount of corticosteroid admin...

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Detalles Bibliográficos
Autores principales: Shono, Tetsuo, Kato, Mayuko, Aoyagi, Yo, Haruna, Hidenori, Fujii, Tohru, Kudo, Takahiro, Ohtsuka, Yoshikazu, Shimizu, Toshiaki
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864444/
https://www.ncbi.nlm.nih.gov/pubmed/20454571
http://dx.doi.org/10.1155/2010/958915
Descripción
Sumario:In Japan, there is as yet no report on growth retardation in children with IBD. We therefore investigated the cause of growth retardation in Japanese children with IBD. We investigated the height, body weight, serum levels of albumin, IGF-I, CRP, and cytokines, and the amount of corticosteroid administered in children with Crohn's disease (CD, n = 15) and ulcerative colitis (UC, n = 18). Our results suggest that growth retardation is already present before the initial visit in children with CD, and chronic inflammation may be responsible this growth disturbance. Moreover, the amount of PSL used may contribute to growth retardation by decreasing the serum levels of IGF-I in children with IBD.

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