Assessment of Growth Disturbance in Japanese Children with IBD

In Japan, there is as yet no report on growth retardation in children with IBD. We therefore investigated the cause of growth retardation in Japanese children with IBD. We investigated the height, body weight, serum levels of albumin, IGF-I, CRP, and cytokines, and the amount of corticosteroid admin...

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Autores principales: Shono, Tetsuo, Kato, Mayuko, Aoyagi, Yo, Haruna, Hidenori, Fujii, Tohru, Kudo, Takahiro, Ohtsuka, Yoshikazu, Shimizu, Toshiaki
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864444/
https://www.ncbi.nlm.nih.gov/pubmed/20454571
http://dx.doi.org/10.1155/2010/958915
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author Shono, Tetsuo
Kato, Mayuko
Aoyagi, Yo
Haruna, Hidenori
Fujii, Tohru
Kudo, Takahiro
Ohtsuka, Yoshikazu
Shimizu, Toshiaki
author_facet Shono, Tetsuo
Kato, Mayuko
Aoyagi, Yo
Haruna, Hidenori
Fujii, Tohru
Kudo, Takahiro
Ohtsuka, Yoshikazu
Shimizu, Toshiaki
author_sort Shono, Tetsuo
collection PubMed
description In Japan, there is as yet no report on growth retardation in children with IBD. We therefore investigated the cause of growth retardation in Japanese children with IBD. We investigated the height, body weight, serum levels of albumin, IGF-I, CRP, and cytokines, and the amount of corticosteroid administered in children with Crohn's disease (CD, n = 15) and ulcerative colitis (UC, n = 18). Our results suggest that growth retardation is already present before the initial visit in children with CD, and chronic inflammation may be responsible this growth disturbance. Moreover, the amount of PSL used may contribute to growth retardation by decreasing the serum levels of IGF-I in children with IBD.
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spelling pubmed-28644442010-05-07 Assessment of Growth Disturbance in Japanese Children with IBD Shono, Tetsuo Kato, Mayuko Aoyagi, Yo Haruna, Hidenori Fujii, Tohru Kudo, Takahiro Ohtsuka, Yoshikazu Shimizu, Toshiaki Int J Pediatr Clinical Study In Japan, there is as yet no report on growth retardation in children with IBD. We therefore investigated the cause of growth retardation in Japanese children with IBD. We investigated the height, body weight, serum levels of albumin, IGF-I, CRP, and cytokines, and the amount of corticosteroid administered in children with Crohn's disease (CD, n = 15) and ulcerative colitis (UC, n = 18). Our results suggest that growth retardation is already present before the initial visit in children with CD, and chronic inflammation may be responsible this growth disturbance. Moreover, the amount of PSL used may contribute to growth retardation by decreasing the serum levels of IGF-I in children with IBD. Hindawi Publishing Corporation 2010 2010-05-05 /pmc/articles/PMC2864444/ /pubmed/20454571 http://dx.doi.org/10.1155/2010/958915 Text en Copyright © 2010 Tetsuo Shono et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Shono, Tetsuo
Kato, Mayuko
Aoyagi, Yo
Haruna, Hidenori
Fujii, Tohru
Kudo, Takahiro
Ohtsuka, Yoshikazu
Shimizu, Toshiaki
Assessment of Growth Disturbance in Japanese Children with IBD
title Assessment of Growth Disturbance in Japanese Children with IBD
title_full Assessment of Growth Disturbance in Japanese Children with IBD
title_fullStr Assessment of Growth Disturbance in Japanese Children with IBD
title_full_unstemmed Assessment of Growth Disturbance in Japanese Children with IBD
title_short Assessment of Growth Disturbance in Japanese Children with IBD
title_sort assessment of growth disturbance in japanese children with ibd
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864444/
https://www.ncbi.nlm.nih.gov/pubmed/20454571
http://dx.doi.org/10.1155/2010/958915
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