Is canalization more than just a beautiful idea?

The heat-shock protein 90 (Hsp90) is currently thought to buffer eukaryotic cells against perturbations caused by pre-existing cryptic genetic variation. A new study suggests that the buffering function of Hsp90 could instead be due to its repression of de novo transposon-mediated mutagenesis.

Detalles Bibliográficos
Autores principales: Sato, Kaoru, Siomi, Haruhiko
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864559/
https://www.ncbi.nlm.nih.gov/pubmed/20236474
http://dx.doi.org/10.1186/gb-2010-11-3-109
Descripción
Sumario:The heat-shock protein 90 (Hsp90) is currently thought to buffer eukaryotic cells against perturbations caused by pre-existing cryptic genetic variation. A new study suggests that the buffering function of Hsp90 could instead be due to its repression of de novo transposon-mediated mutagenesis.

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