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Inflammatory Molecules in Aqueous Humour and on Ocular Surface and Glaucoma Surgery Outcome
Purpose. To investigate the influence of inflammatory molecules in the aqueous humour and on the ocular surface on the outcome of glaucoma surgery. Methods. Thirty patients who needed antiglaucomatous surgery were included. The interleukin- (IL-) 8, IL-1β, IL-6, IL-10, tumour necrosis factor- (TNF-)...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864908/ https://www.ncbi.nlm.nih.gov/pubmed/20467456 http://dx.doi.org/10.1155/2010/939602 |
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author | Cvenkel, Barbara Kopitar, Andreja Nataša Ihan, Alojz |
author_facet | Cvenkel, Barbara Kopitar, Andreja Nataša Ihan, Alojz |
author_sort | Cvenkel, Barbara |
collection | PubMed |
description | Purpose. To investigate the influence of inflammatory molecules in the aqueous humour and on the ocular surface on the outcome of glaucoma surgery. Methods. Thirty patients who needed antiglaucomatous surgery were included. The interleukin- (IL-) 8, IL-1β, IL-6, IL-10, tumour necrosis factor- (TNF-) α; and IL-12 were determined from aqueous humour preoperatively and the imprints of conjunctiva were analysed for expression of human leukocyte antigen- (HLA-)-DR after surgery by flow cytometry. The success of trabeculectomy was defined as intraocular pressure less than 21 mmHg without antiglaucoma medication. Results. Eyes with trabeculectomy failure at 3 months showed significantly higher TNF-α and IL-6 levels in the aqueous than eyes with successful surgery. Increased expression of HLA-DR on epithelial cells and antigen-presenting cells was not associated with the trabeculectomy outcome. Conclusions. Higher preoperative levels of TNF-α and IL-6 in aqueous humour may contribute to the development of inflammatory milieu and were associated with worse outcome of glaucoma surgery. |
format | Text |
id | pubmed-2864908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28649082010-05-13 Inflammatory Molecules in Aqueous Humour and on Ocular Surface and Glaucoma Surgery Outcome Cvenkel, Barbara Kopitar, Andreja Nataša Ihan, Alojz Mediators Inflamm Clinical Study Purpose. To investigate the influence of inflammatory molecules in the aqueous humour and on the ocular surface on the outcome of glaucoma surgery. Methods. Thirty patients who needed antiglaucomatous surgery were included. The interleukin- (IL-) 8, IL-1β, IL-6, IL-10, tumour necrosis factor- (TNF-) α; and IL-12 were determined from aqueous humour preoperatively and the imprints of conjunctiva were analysed for expression of human leukocyte antigen- (HLA-)-DR after surgery by flow cytometry. The success of trabeculectomy was defined as intraocular pressure less than 21 mmHg without antiglaucoma medication. Results. Eyes with trabeculectomy failure at 3 months showed significantly higher TNF-α and IL-6 levels in the aqueous than eyes with successful surgery. Increased expression of HLA-DR on epithelial cells and antigen-presenting cells was not associated with the trabeculectomy outcome. Conclusions. Higher preoperative levels of TNF-α and IL-6 in aqueous humour may contribute to the development of inflammatory milieu and were associated with worse outcome of glaucoma surgery. Hindawi Publishing Corporation 2010 2010-05-05 /pmc/articles/PMC2864908/ /pubmed/20467456 http://dx.doi.org/10.1155/2010/939602 Text en Copyright © 2010 Barbara Cvenkel et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Cvenkel, Barbara Kopitar, Andreja Nataša Ihan, Alojz Inflammatory Molecules in Aqueous Humour and on Ocular Surface and Glaucoma Surgery Outcome |
title | Inflammatory Molecules in Aqueous Humour and on Ocular Surface and Glaucoma Surgery Outcome |
title_full | Inflammatory Molecules in Aqueous Humour and on Ocular Surface and Glaucoma Surgery Outcome |
title_fullStr | Inflammatory Molecules in Aqueous Humour and on Ocular Surface and Glaucoma Surgery Outcome |
title_full_unstemmed | Inflammatory Molecules in Aqueous Humour and on Ocular Surface and Glaucoma Surgery Outcome |
title_short | Inflammatory Molecules in Aqueous Humour and on Ocular Surface and Glaucoma Surgery Outcome |
title_sort | inflammatory molecules in aqueous humour and on ocular surface and glaucoma surgery outcome |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864908/ https://www.ncbi.nlm.nih.gov/pubmed/20467456 http://dx.doi.org/10.1155/2010/939602 |
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