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Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization, natural biodistribution, and acute toxicity

The clinical outcome of patients with ischemic heart disease can be significantly improved with the implementation of targeted drug delivery into the ischemic myocardium. In this paper, we present our original findings relevant to the problem of therapeutic heart targeting with use of nanoparticles....

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Autores principales: Galagudza, Michael M, Korolev, Dmitry V, Sonin, Dmitry L, Postnov, Viktor N, Papayan, Garry V, Uskov, Ivan S, Belozertseva, Anastasia V, Shlyakhto, Eugene V
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865018/
https://www.ncbi.nlm.nih.gov/pubmed/20463939
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author Galagudza, Michael M
Korolev, Dmitry V
Sonin, Dmitry L
Postnov, Viktor N
Papayan, Garry V
Uskov, Ivan S
Belozertseva, Anastasia V
Shlyakhto, Eugene V
author_facet Galagudza, Michael M
Korolev, Dmitry V
Sonin, Dmitry L
Postnov, Viktor N
Papayan, Garry V
Uskov, Ivan S
Belozertseva, Anastasia V
Shlyakhto, Eugene V
author_sort Galagudza, Michael M
collection PubMed
description The clinical outcome of patients with ischemic heart disease can be significantly improved with the implementation of targeted drug delivery into the ischemic myocardium. In this paper, we present our original findings relevant to the problem of therapeutic heart targeting with use of nanoparticles. Experimental approaches included fabrication of carbon and silica nanoparticles, their characterization and surface modification. The acute hemodynamic effects of nanoparticle formulation as well as nanoparticle biodistribution were studied in male Wistar rats. Carbon and silica nanoparticles are nontoxic materials that can be used as carriers for heart-targeted drug delivery. Concepts of passive and active targeting can be applied to the development of targeted drug delivery to the ischemic myocardial cells. Provided that ischemic heart-targeted drug delivery can be proved to be safe and efficient, the results of this research may contribute to the development of new technologies in the pharmaceutical industry.
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spelling pubmed-28650182010-05-12 Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization, natural biodistribution, and acute toxicity Galagudza, Michael M Korolev, Dmitry V Sonin, Dmitry L Postnov, Viktor N Papayan, Garry V Uskov, Ivan S Belozertseva, Anastasia V Shlyakhto, Eugene V Int J Nanomedicine Original Research The clinical outcome of patients with ischemic heart disease can be significantly improved with the implementation of targeted drug delivery into the ischemic myocardium. In this paper, we present our original findings relevant to the problem of therapeutic heart targeting with use of nanoparticles. Experimental approaches included fabrication of carbon and silica nanoparticles, their characterization and surface modification. The acute hemodynamic effects of nanoparticle formulation as well as nanoparticle biodistribution were studied in male Wistar rats. Carbon and silica nanoparticles are nontoxic materials that can be used as carriers for heart-targeted drug delivery. Concepts of passive and active targeting can be applied to the development of targeted drug delivery to the ischemic myocardial cells. Provided that ischemic heart-targeted drug delivery can be proved to be safe and efficient, the results of this research may contribute to the development of new technologies in the pharmaceutical industry. Dove Medical Press 2010 2010-04-07 /pmc/articles/PMC2865018/ /pubmed/20463939 Text en © 2010 Galagudza et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Galagudza, Michael M
Korolev, Dmitry V
Sonin, Dmitry L
Postnov, Viktor N
Papayan, Garry V
Uskov, Ivan S
Belozertseva, Anastasia V
Shlyakhto, Eugene V
Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization, natural biodistribution, and acute toxicity
title Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization, natural biodistribution, and acute toxicity
title_full Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization, natural biodistribution, and acute toxicity
title_fullStr Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization, natural biodistribution, and acute toxicity
title_full_unstemmed Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization, natural biodistribution, and acute toxicity
title_short Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization, natural biodistribution, and acute toxicity
title_sort targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization, natural biodistribution, and acute toxicity
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865018/
https://www.ncbi.nlm.nih.gov/pubmed/20463939
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