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Structure-Based Discovery of A(2A) Adenosine Receptor Ligands

[Image: see text] The recent determination of X-ray structures of pharmacologically relevant GPCRs has made these targets accessible to structure-based ligand discovery. Here we explore whether novel chemotypes may be discovered for the A(2A) adenosine receptor, based on complementarity to its recen...

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Detalles Bibliográficos
Autores principales:	Carlsson, Jens, Yoo, Lena, Gao, Zhan-Guo, Irwin, John J., Shoichet, Brian K., Jacobson, Kenneth A.
Formato:	Texto
Lenguaje:	English
Publicado:	American Chemical Society 2010
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865168/ https://www.ncbi.nlm.nih.gov/pubmed/20405927 http://dx.doi.org/10.1021/jm100240h

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