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Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunction

In polyglutamine diseases including Huntington's disease (HD), mutant proteins containing expanded polyglutamine stretches form nuclear aggregates in neurons. Although analysis of their disease models suggested a significance of transcriptional dysregulation in these diseases, how it mediates t...

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Detalles Bibliográficos
Autores principales:	Yamanaka, Tomoyuki, Tosaki, Asako, Miyazaki, Haruko, Kurosawa, Masaru, Furukawa, Yoshiaki, Yamada, Mizuki, Nukina, Nobuyuki
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865370/ https://www.ncbi.nlm.nih.gov/pubmed/20185558 http://dx.doi.org/10.1093/hmg/ddq087

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