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Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by a polyglutamine expansion in huntingtin. There are no treatments that are known to slow the neurodegeneration caused by this mutation. Mutant huntingtin causes disease via a toxic gain-of-function mechanism a...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865373/ https://www.ncbi.nlm.nih.gov/pubmed/20190273 http://dx.doi.org/10.1093/hmg/ddq093 |