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Channeling by Proximity: The Catalytic Advantages of Active Site Colocalization Using Brownian Dynamics
[Image: see text] Nature often colocalizes successive steps in a metabolic pathway. Such organization is predicted to increase the effective concentration of pathway intermediates near their recipient active sites and to enhance catalytic efficiency. Here, the pathway of a two-step reaction is model...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865391/ https://www.ncbi.nlm.nih.gov/pubmed/20454551 http://dx.doi.org/10.1021/jz1002007 |