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Intrauterine growth restriction and placental angiogenesis

BACKGROUND: Vascular endothelial growth factor (VEGF), basic-fibroblast growth factor (b-FGF), and endothelial nitric oxide synthase (eNOS) are factors that take part in placental angiogenesis. They are highly expressed during embryonic and fetal development, especially in the first trimester. In th...

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Autores principales: Barut, Figen, Barut, Aykut, Gun, Banu Dogan, Kandemir, Nilufer Onak, Harma, Mehmet Ibrahim, Harma, Muge, Aktunc, Erol, Ozdamar, Sukru Oguz
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865442/
https://www.ncbi.nlm.nih.gov/pubmed/20412591
http://dx.doi.org/10.1186/1746-1596-5-24
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author Barut, Figen
Barut, Aykut
Gun, Banu Dogan
Kandemir, Nilufer Onak
Harma, Mehmet Ibrahim
Harma, Muge
Aktunc, Erol
Ozdamar, Sukru Oguz
author_facet Barut, Figen
Barut, Aykut
Gun, Banu Dogan
Kandemir, Nilufer Onak
Harma, Mehmet Ibrahim
Harma, Muge
Aktunc, Erol
Ozdamar, Sukru Oguz
author_sort Barut, Figen
collection PubMed
description BACKGROUND: Vascular endothelial growth factor (VEGF), basic-fibroblast growth factor (b-FGF), and endothelial nitric oxide synthase (eNOS) are factors that take part in placental angiogenesis. They are highly expressed during embryonic and fetal development, especially in the first trimester. In this study, we aimed to investigate the role of placental angiogenesis in the development of intrauterine growth restriction (IUGR) by comparing the levels of expression of VEGF-A, b-FGF, and eNOS in normal-term pregnancy and IUGR placentas. METHODS: The expression of VEGF-A, b-FGF, and eNOS was studied using the avidin-biotin-peroxidase method in placental tissues diagnosed as normal (n = 55) and IUGR (n = 55). Results were evaluated in a semi-quantitative manner. RESULTS: The expression of all the markers was significantly higher (p < 0.001) in cytotrophoblasts, syncytiotrophoblasts, extravillous trophoblasts, vascular smooth muscle cells, chorionic villous stromal cells, and villous vascular endothelial cells of the IUGR placentas when compared with those collected from normal-term pregnancies. CONCLUSION: Increased expression of VEGF-A, b-FGF, and eNOS may be the result of inadequate uteroplacental perfusion, supporting the proposal that abnormal angiogenesis plays a role in the pathophysiology of IUGR.
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spelling pubmed-28654422010-05-07 Intrauterine growth restriction and placental angiogenesis Barut, Figen Barut, Aykut Gun, Banu Dogan Kandemir, Nilufer Onak Harma, Mehmet Ibrahim Harma, Muge Aktunc, Erol Ozdamar, Sukru Oguz Diagn Pathol Research BACKGROUND: Vascular endothelial growth factor (VEGF), basic-fibroblast growth factor (b-FGF), and endothelial nitric oxide synthase (eNOS) are factors that take part in placental angiogenesis. They are highly expressed during embryonic and fetal development, especially in the first trimester. In this study, we aimed to investigate the role of placental angiogenesis in the development of intrauterine growth restriction (IUGR) by comparing the levels of expression of VEGF-A, b-FGF, and eNOS in normal-term pregnancy and IUGR placentas. METHODS: The expression of VEGF-A, b-FGF, and eNOS was studied using the avidin-biotin-peroxidase method in placental tissues diagnosed as normal (n = 55) and IUGR (n = 55). Results were evaluated in a semi-quantitative manner. RESULTS: The expression of all the markers was significantly higher (p < 0.001) in cytotrophoblasts, syncytiotrophoblasts, extravillous trophoblasts, vascular smooth muscle cells, chorionic villous stromal cells, and villous vascular endothelial cells of the IUGR placentas when compared with those collected from normal-term pregnancies. CONCLUSION: Increased expression of VEGF-A, b-FGF, and eNOS may be the result of inadequate uteroplacental perfusion, supporting the proposal that abnormal angiogenesis plays a role in the pathophysiology of IUGR. BioMed Central 2010-04-22 /pmc/articles/PMC2865442/ /pubmed/20412591 http://dx.doi.org/10.1186/1746-1596-5-24 Text en Copyright ©2010 Barut et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Barut, Figen
Barut, Aykut
Gun, Banu Dogan
Kandemir, Nilufer Onak
Harma, Mehmet Ibrahim
Harma, Muge
Aktunc, Erol
Ozdamar, Sukru Oguz
Intrauterine growth restriction and placental angiogenesis
title Intrauterine growth restriction and placental angiogenesis
title_full Intrauterine growth restriction and placental angiogenesis
title_fullStr Intrauterine growth restriction and placental angiogenesis
title_full_unstemmed Intrauterine growth restriction and placental angiogenesis
title_short Intrauterine growth restriction and placental angiogenesis
title_sort intrauterine growth restriction and placental angiogenesis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865442/
https://www.ncbi.nlm.nih.gov/pubmed/20412591
http://dx.doi.org/10.1186/1746-1596-5-24
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