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Kainic acid-induced microglial activation is attenuated in aged interleukin-18 deficient mice

BACKGROUND: Previously, we found that interleukin (IL)-18 deficiency aggravates kainic acid (KA)-induced hippocampal neurodegeneration in young C57BL/6 mice due to an over-compensation by IL-12. Additionally, IL-18 participates in fundamental inflammatory processes that increase during aging. In the...

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Detalles Bibliográficos
Autores principales:	Zhang, Xing-Mei, Jin, Tao, Quezada, Hernan Concha, Mix, Eilhard, Winblad, Bengt, Zhu, Jie
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865455/ https://www.ncbi.nlm.nih.gov/pubmed/20398244 http://dx.doi.org/10.1186/1742-2094-7-26

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