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Malnutrition and inflammation in acute kidney injury due to earthquake-related crush syndrome

BACKGROUND: Malnutrition and inflammation are common and serious complications in patients with acute kidney injury (AKI). However, the profile of these complications in patients with AKI caused by crush syndrome (CS) remains unclear. This study describes the clinical characteristics of malnutrition...

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Autores principales: Li, Gui-Sen, Chen, Xiu-Ling, Zhang, Yuan, He, Qiang, Wang, Fang, Hong, Da-Qing, Zhang, Ping, Pu, Lei, Zhang, Yue, Yang, Xiu-Chuan, Wang, Li
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865457/
https://www.ncbi.nlm.nih.gov/pubmed/20346168
http://dx.doi.org/10.1186/1471-2369-11-4
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author Li, Gui-Sen
Chen, Xiu-Ling
Zhang, Yuan
He, Qiang
Wang, Fang
Hong, Da-Qing
Zhang, Ping
Pu, Lei
Zhang, Yue
Yang, Xiu-Chuan
Wang, Li
author_facet Li, Gui-Sen
Chen, Xiu-Ling
Zhang, Yuan
He, Qiang
Wang, Fang
Hong, Da-Qing
Zhang, Ping
Pu, Lei
Zhang, Yue
Yang, Xiu-Chuan
Wang, Li
author_sort Li, Gui-Sen
collection PubMed
description BACKGROUND: Malnutrition and inflammation are common and serious complications in patients with acute kidney injury (AKI). However, the profile of these complications in patients with AKI caused by crush syndrome (CS) remains unclear. This study describes the clinical characteristics of malnutrition and inflammation in patients with AKI and CS due to the Wenchuan earthquake. METHODS: One thousand and twelve victims and eighteen healthy adults were recruited to the study. They were divided into five groups: Group A was composed of victims without CS and AKI (904 cases); Group B was composed of patients with CS and AKI who haven't received renal replacement therapy (RRT) (57 cases); and Group C was composed of patients with CS and AKI receiving RRT (25 cases); Group D was composed of earthquake victims with AKI but without CS (26 cases); and Group E was composed of 18 healthy adult controls. The C-reactive protein (CRP), prealbumin, transferrin, interleukin-6 and TNF-α were measured and compared between Group E and 18 patients from Group C. RESULTS: The results indicate that participants in Group C had the highest level of serum creatinine, blood urea nitrogen and uric acid. Approximately 92% of patients with CS who had RRT were suffering from hypoalbuminemia. The interleukin-6 and CRP levels were significantly higher in patients with CS AKI receiving RRT than in the control group. Patients in Group C received the highest dosages of albumin, plasma or red blood cell transfusions. One patient in Group C died during treatment. CONCLUSIONS: Malnutrition and inflammation was common in patients with earthquake-related CS and had a negative impact on the prognosis of these subjects. The results of this study indicate that the use of RRT, intensive nutritional supplementation and transfusion alleviated the degree of malnutrition and inflammation in hemodialysis patients with crush syndrome.
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spelling pubmed-28654572010-05-07 Malnutrition and inflammation in acute kidney injury due to earthquake-related crush syndrome Li, Gui-Sen Chen, Xiu-Ling Zhang, Yuan He, Qiang Wang, Fang Hong, Da-Qing Zhang, Ping Pu, Lei Zhang, Yue Yang, Xiu-Chuan Wang, Li BMC Nephrol Research article BACKGROUND: Malnutrition and inflammation are common and serious complications in patients with acute kidney injury (AKI). However, the profile of these complications in patients with AKI caused by crush syndrome (CS) remains unclear. This study describes the clinical characteristics of malnutrition and inflammation in patients with AKI and CS due to the Wenchuan earthquake. METHODS: One thousand and twelve victims and eighteen healthy adults were recruited to the study. They were divided into five groups: Group A was composed of victims without CS and AKI (904 cases); Group B was composed of patients with CS and AKI who haven't received renal replacement therapy (RRT) (57 cases); and Group C was composed of patients with CS and AKI receiving RRT (25 cases); Group D was composed of earthquake victims with AKI but without CS (26 cases); and Group E was composed of 18 healthy adult controls. The C-reactive protein (CRP), prealbumin, transferrin, interleukin-6 and TNF-α were measured and compared between Group E and 18 patients from Group C. RESULTS: The results indicate that participants in Group C had the highest level of serum creatinine, blood urea nitrogen and uric acid. Approximately 92% of patients with CS who had RRT were suffering from hypoalbuminemia. The interleukin-6 and CRP levels were significantly higher in patients with CS AKI receiving RRT than in the control group. Patients in Group C received the highest dosages of albumin, plasma or red blood cell transfusions. One patient in Group C died during treatment. CONCLUSIONS: Malnutrition and inflammation was common in patients with earthquake-related CS and had a negative impact on the prognosis of these subjects. The results of this study indicate that the use of RRT, intensive nutritional supplementation and transfusion alleviated the degree of malnutrition and inflammation in hemodialysis patients with crush syndrome. BioMed Central 2010-03-27 /pmc/articles/PMC2865457/ /pubmed/20346168 http://dx.doi.org/10.1186/1471-2369-11-4 Text en Copyright ©2010 Li et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research article
Li, Gui-Sen
Chen, Xiu-Ling
Zhang, Yuan
He, Qiang
Wang, Fang
Hong, Da-Qing
Zhang, Ping
Pu, Lei
Zhang, Yue
Yang, Xiu-Chuan
Wang, Li
Malnutrition and inflammation in acute kidney injury due to earthquake-related crush syndrome
title Malnutrition and inflammation in acute kidney injury due to earthquake-related crush syndrome
title_full Malnutrition and inflammation in acute kidney injury due to earthquake-related crush syndrome
title_fullStr Malnutrition and inflammation in acute kidney injury due to earthquake-related crush syndrome
title_full_unstemmed Malnutrition and inflammation in acute kidney injury due to earthquake-related crush syndrome
title_short Malnutrition and inflammation in acute kidney injury due to earthquake-related crush syndrome
title_sort malnutrition and inflammation in acute kidney injury due to earthquake-related crush syndrome
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865457/
https://www.ncbi.nlm.nih.gov/pubmed/20346168
http://dx.doi.org/10.1186/1471-2369-11-4
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