Cargando…

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

BACKGROUND: Microglia provide continuous immune surveillance of the CNS and upon activation rapidly change phenotype to express receptors that respond to chemoattractants during CNS damage or infection. These activated microglia undergo directed migration towards affected tissue. Importantly, the mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	McHugh, Douglas, Hu, Sherry SJ, Rimmerman, Neta, Juknat, Ana, Vogel, Zvi, Walker, J Michael, Bradshaw, Heather B
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865488/ https://www.ncbi.nlm.nih.gov/pubmed/20346144 http://dx.doi.org/10.1186/1471-2202-11-44

Ejemplares similares

The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways
por: Bradshaw, Heather B, et al.
Publicado: (2009)

siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycine-induced cell migration
por: McHugh, Douglas, et al.
Publicado: (2012)

Δ(9)-THC and N-arachidonoyl glycine regulate BV-2 microglial morphology and cytokine release plasticity: implications for signaling at GPR18
por: McHugh, Douglas, et al.
Publicado: (2014)

GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-Arachidonoyl Glycine
por: Finlay, David B., et al.
Publicado: (2016)

Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid
por: Kozela, Ewa, et al.
Publicado: (2017)

Protective Effect of N-Arachidonoyl Glycine-GPR18 Signaling after Excitotoxical Lesion in Murine Organotypic Hippocampal Slice Cultures
por: Grabiec, Urszula, et al.
Publicado: (2019)

Microarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated Modulation of LPS-Induced Activation of BV-2 Microglial Cells
por: Juknat, Ana, et al.
Publicado: (2013)

Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death
por: Rimmerman, N, et al.
Publicado: (2013)

Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells
por: Kozela, Ewa, et al.
Publicado: (2016)

Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells
por: Kozela, Ewa, et al.
Publicado: (2015)

Effects of TRPV1 Activation by Capsaicin and Endogenous N-Arachidonoyl Taurine on Synaptic Transmission in the Prefrontal Cortex
por: Zhang, Mingyue, et al.
Publicado: (2020)

Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β(2) subunit of GABA(A) receptors?
por: Baur, Roland, et al.
Publicado: (2013)

Arachidonoyl-Phospholipid Remodeling in Proliferating Murine T Cells
por: Tomita, Michiyo, et al.
Publicado: (2004)

Inhibition of store-operated calcium channels by N-arachidonoyl glycine (NAGly): no evidence for the involvement of lipid-sensing G protein coupled receptors
por: Deveci, Aykut, et al.
Publicado: (2020)

Arachidonoyl-Specific Diacylglycerol Kinase ε and the Endoplasmic Reticulum
por: Nakano, Tomoyuki, et al.
Publicado: (2016)

Effect of N-arachidonoyl-l-serine on human cerebromicrovascular endothelium()
por: Kino, Tomoyuki, et al.
Publicado: (2016)

N-arachidonoyl glycine suppresses Na(+)/Ca(2+) exchanger-mediated Ca(2+) entry into endothelial cells and activates BK(Ca) channels independently of GPCRs
por: Bondarenko, Alexander I, et al.
Publicado: (2013)

Osteogenic growth peptide is a potent anti-inflammatory and bone preserving hormone via cannabinoid receptor type 2
por: Raphael-Mizrahi, Bitya, et al.
Publicado: (2022)

Glycine Effect on the Expression Profile of Orphan Receptors GPR21, GPR26, GPR39, GPR82 and GPR6 in a Model of Inflammation in 3T3-L1 Cells
por: Gutiérrez-Rojas, Rocío Alejandra, et al.
Publicado: (2022)

Potential Metabolic and Behavioural Roles of the Putative Endo- cannabinoid Receptors GPR18, GPR55 and GPR119 in Feeding
por: Ramírez-Orozco, Ricardo E., et al.
Publicado: (2019)

miRNA expression profiles and molecular networks in resting and LPS-activated BV-2 microglia—Effect of cannabinoids
por: Juknat, Ana, et al.
Publicado: (2019)

Endocannabinoid 2-arachidonoyl glycerol increases the transcription of daf-7 in ASI neurons
por: Galles, Celina, et al.
Publicado: (2018)

The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption
por: Ding, Weihua, et al.
Publicado: (2023)

Investigating the Putative Glycine Hinge in Shaker Potassium Channel
por: Ding, Shinghua, et al.
Publicado: (2005)

Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and Its Putative Receptors GPR18 and GPR55
por: Guerrero-Alba, Raquel, et al.
Publicado: (2019)

Elevated Serum Levels of Arachidonoyl-lysophosphatidic Acid and Sphingosine 1-Phosphate in Systemic Sclerosis
por: Tokumura, Akira, et al.
Publicado: (2009)

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion
por: Rong, Xin, et al.
Publicado: (2015)

N-Arachidonoyl Dopamine: A Novel Endocannabinoid and Endovanilloid with Widespread Physiological and Pharmacological Activities
por: Grabiec, Urszula, et al.
Publicado: (2017)

Erratum: Endocannabinoid 2-arachidonoyl glycerol increases the transcription of daf-7 in ASI neurons
Publicado: (2019)

NO(●) Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis
por: Mikulska-Ruminska, Karolina, et al.
Publicado: (2021)

Expression of the putative cannabinoid receptor GPR55 is increased in endometrial carcinoma
por: Ayakannu, Thangesweran, et al.
Publicado: (2021)

Author Correction: The endocannabinoid N-arachidonoyl dopamine is critical for hyperalgesia induced by chronic sleep disruption
por: Ding, Weihua, et al.
Publicado: (2023)

An innovative electrochemical immuno-platform towards ultra-sensitive monitoring of 2-arachidonoyl glycerol in samples from rats with sleep deprivation: bioanalysis of endogenous cannabinoids using biosensor technology
por: Kohansal, Fereshteh, et al.
Publicado: (2022)

Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918
por: Stott, Lisa A., et al.
Publicado: (2021)

The Cytotoxic Effects of Cannabidiol and Cannabigerol on Glioblastoma Stem Cells May Mostly Involve GPR55 and TRPV1 Signalling
por: Lah, Tamara T., et al.
Publicado: (2022)

Cooccurrences of Putative Endogenous Retrovirus-Associated Diseases
por: Brütting, Christine, et al.
Publicado: (2017)

Investigations of the Contribution of a Putative Glycine Hinge to Ryanodine Receptor Channel Gating
por: Euden, Joanne, et al.
Publicado: (2013)

A Cannabinoid Receptor Agonist N-Arachidonoyl Dopamine Inhibits Adipocyte Differentiation in Human Mesenchymal Stem Cells
por: Ahn, Seyeon, et al.
Publicado: (2015)

Human and Mouse Eosinophils Differ in Their Ability to Biosynthesize Eicosanoids, Docosanoids, the Endocannabinoid 2-Arachidonoyl-glycerol and Its Congeners
por: Archambault, Anne-Sophie, et al.
Publicado: (2022)

Potent Activity of Hybrid Arthropod Antimicrobial Peptides Linked by Glycine Spacers
por: Tonk, Miray, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_d1khbo8atbi58ta33q0vjonb48