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Myeloid Cell-Restricted Insulin Receptor Deficiency Protects Against Obesity-Induced Inflammation and Systemic Insulin Resistance

A major component of obesity-related insulin resistance is the establishment of a chronic inflammatory state with invasion of white adipose tissue by mononuclear cells. This results in the release of pro-inflammatory cytokines, which in turn leads to insulin resistance in target tissues such as skel...

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Detalles Bibliográficos
Autores principales:	Mauer, Jan, Chaurasia, Bhagirath, Plum, Leona, Quast, Thomas, Hampel, Brigitte, Blüher, Matthias, Kolanus, Waldemar, Kahn, C. Ronald, Brüning, Jens C.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865520/ https://www.ncbi.nlm.nih.gov/pubmed/20463885 http://dx.doi.org/10.1371/journal.pgen.1000938

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