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Surgery for colorectal liver metastases

In this review the surgery of colorectal liver metastases is discussed. It has long been known that liver surgery can cure metastatic colorectal cancer although in only a small proportion of the population with the disease. However with better understanding of the natural history of the condition an...

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Detalles Bibliográficos
Autor principal: Primrose, J N
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865767/
https://www.ncbi.nlm.nih.gov/pubmed/20424612
http://dx.doi.org/10.1038/sj.bjc.6605659
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author Primrose, J N
author_facet Primrose, J N
author_sort Primrose, J N
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description In this review the surgery of colorectal liver metastases is discussed. It has long been known that liver surgery can cure metastatic colorectal cancer although in only a small proportion of the population with the disease. However with better understanding of the natural history of the condition and advances in technique more patients can have safe, potentially curative surgery. The multidiscipline management of patients with effective chemotherapy has led to more patients benefiting from surgery after reducing the size of the metastases and allowing operation on patients who were previously inoperable. Chemotherapy also improves at least the medium-term outcome in those who are operable at the outset. Minimally invasive techniques have been developed so that major hepatectomy may be accomplished in up to half of such cases with a very short hospital stay and limited interference with quality of life. Lastly, using portal vein embolisation to cause hypertrophy of the future liver remnant and on occasions combining it with staged liver resection allows potentially curative surgery on patients who previously could not have survived resection. These developments have led to more patients being cured of advanced colorectal cancer.
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spelling pubmed-28657672011-04-27 Surgery for colorectal liver metastases Primrose, J N Br J Cancer Minireview In this review the surgery of colorectal liver metastases is discussed. It has long been known that liver surgery can cure metastatic colorectal cancer although in only a small proportion of the population with the disease. However with better understanding of the natural history of the condition and advances in technique more patients can have safe, potentially curative surgery. The multidiscipline management of patients with effective chemotherapy has led to more patients benefiting from surgery after reducing the size of the metastases and allowing operation on patients who were previously inoperable. Chemotherapy also improves at least the medium-term outcome in those who are operable at the outset. Minimally invasive techniques have been developed so that major hepatectomy may be accomplished in up to half of such cases with a very short hospital stay and limited interference with quality of life. Lastly, using portal vein embolisation to cause hypertrophy of the future liver remnant and on occasions combining it with staged liver resection allows potentially curative surgery on patients who previously could not have survived resection. These developments have led to more patients being cured of advanced colorectal cancer. Nature Publishing Group 2010-04-27 2010-04-27 /pmc/articles/PMC2865767/ /pubmed/20424612 http://dx.doi.org/10.1038/sj.bjc.6605659 Text en Copyright © 2010 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Primrose, J N
Surgery for colorectal liver metastases
title Surgery for colorectal liver metastases
title_full Surgery for colorectal liver metastases
title_fullStr Surgery for colorectal liver metastases
title_full_unstemmed Surgery for colorectal liver metastases
title_short Surgery for colorectal liver metastases
title_sort surgery for colorectal liver metastases
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865767/
https://www.ncbi.nlm.nih.gov/pubmed/20424612
http://dx.doi.org/10.1038/sj.bjc.6605659
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