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Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent

In the present investigation 0.5 M ibuprofen sodium solution has been used as hydrotropic solubilizing agent for naproxen, a poorly water-soluble drug and in it there was more than 350 fold enhancement in the solubility of naproxen as compared to the solubility in distilled water. Therefore, this hy...

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Autores principales: Maheshwari, R. K., Wanare, G., Chahar, Nitika, Joshi, Prajakta, Nayak, Nishi
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865801/
https://www.ncbi.nlm.nih.gov/pubmed/20490309
http://dx.doi.org/10.4103/0250-474X.56020
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author Maheshwari, R. K.
Wanare, G.
Chahar, Nitika
Joshi, Prajakta
Nayak, Nishi
author_facet Maheshwari, R. K.
Wanare, G.
Chahar, Nitika
Joshi, Prajakta
Nayak, Nishi
author_sort Maheshwari, R. K.
collection PubMed
description In the present investigation 0.5 M ibuprofen sodium solution has been used as hydrotropic solubilizing agent for naproxen, a poorly water-soluble drug and in it there was more than 350 fold enhancement in the solubility of naproxen as compared to the solubility in distilled water. Therefore, this hydrotropic solution was employed to extract out the drug from its tablet dosage form for quantitative estimation by titrimetry. The naproxen has been successfully analyzed in tablets. The results of analysis obtained by proposed method compared well with those by corresponding British pharmacopoeial method involving the use of methanol. The proposed method was also validated by recovery studies. Presence of ibuprofen sodium and common excipients did not interfere in analysis. Proposed method is new, simple, economic, safe, rapid, accurate, reproducible and environment-friendly.
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spelling pubmed-28658012010-05-20 Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent Maheshwari, R. K. Wanare, G. Chahar, Nitika Joshi, Prajakta Nayak, Nishi Indian J Pharm Sci Short Communication In the present investigation 0.5 M ibuprofen sodium solution has been used as hydrotropic solubilizing agent for naproxen, a poorly water-soluble drug and in it there was more than 350 fold enhancement in the solubility of naproxen as compared to the solubility in distilled water. Therefore, this hydrotropic solution was employed to extract out the drug from its tablet dosage form for quantitative estimation by titrimetry. The naproxen has been successfully analyzed in tablets. The results of analysis obtained by proposed method compared well with those by corresponding British pharmacopoeial method involving the use of methanol. The proposed method was also validated by recovery studies. Presence of ibuprofen sodium and common excipients did not interfere in analysis. Proposed method is new, simple, economic, safe, rapid, accurate, reproducible and environment-friendly. Medknow Publications 2009 /pmc/articles/PMC2865801/ /pubmed/20490309 http://dx.doi.org/10.4103/0250-474X.56020 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Maheshwari, R. K.
Wanare, G.
Chahar, Nitika
Joshi, Prajakta
Nayak, Nishi
Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent
title Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent
title_full Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent
title_fullStr Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent
title_full_unstemmed Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent
title_short Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent
title_sort quantitative estimation of naproxen in tablets using ibuprofen sodium as hydrotropic agent
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865801/
https://www.ncbi.nlm.nih.gov/pubmed/20490309
http://dx.doi.org/10.4103/0250-474X.56020
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