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Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent
In the present investigation 0.5 M ibuprofen sodium solution has been used as hydrotropic solubilizing agent for naproxen, a poorly water-soluble drug and in it there was more than 350 fold enhancement in the solubility of naproxen as compared to the solubility in distilled water. Therefore, this hy...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865801/ https://www.ncbi.nlm.nih.gov/pubmed/20490309 http://dx.doi.org/10.4103/0250-474X.56020 |
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author | Maheshwari, R. K. Wanare, G. Chahar, Nitika Joshi, Prajakta Nayak, Nishi |
author_facet | Maheshwari, R. K. Wanare, G. Chahar, Nitika Joshi, Prajakta Nayak, Nishi |
author_sort | Maheshwari, R. K. |
collection | PubMed |
description | In the present investigation 0.5 M ibuprofen sodium solution has been used as hydrotropic solubilizing agent for naproxen, a poorly water-soluble drug and in it there was more than 350 fold enhancement in the solubility of naproxen as compared to the solubility in distilled water. Therefore, this hydrotropic solution was employed to extract out the drug from its tablet dosage form for quantitative estimation by titrimetry. The naproxen has been successfully analyzed in tablets. The results of analysis obtained by proposed method compared well with those by corresponding British pharmacopoeial method involving the use of methanol. The proposed method was also validated by recovery studies. Presence of ibuprofen sodium and common excipients did not interfere in analysis. Proposed method is new, simple, economic, safe, rapid, accurate, reproducible and environment-friendly. |
format | Text |
id | pubmed-2865801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28658012010-05-20 Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent Maheshwari, R. K. Wanare, G. Chahar, Nitika Joshi, Prajakta Nayak, Nishi Indian J Pharm Sci Short Communication In the present investigation 0.5 M ibuprofen sodium solution has been used as hydrotropic solubilizing agent for naproxen, a poorly water-soluble drug and in it there was more than 350 fold enhancement in the solubility of naproxen as compared to the solubility in distilled water. Therefore, this hydrotropic solution was employed to extract out the drug from its tablet dosage form for quantitative estimation by titrimetry. The naproxen has been successfully analyzed in tablets. The results of analysis obtained by proposed method compared well with those by corresponding British pharmacopoeial method involving the use of methanol. The proposed method was also validated by recovery studies. Presence of ibuprofen sodium and common excipients did not interfere in analysis. Proposed method is new, simple, economic, safe, rapid, accurate, reproducible and environment-friendly. Medknow Publications 2009 /pmc/articles/PMC2865801/ /pubmed/20490309 http://dx.doi.org/10.4103/0250-474X.56020 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Maheshwari, R. K. Wanare, G. Chahar, Nitika Joshi, Prajakta Nayak, Nishi Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent |
title | Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent |
title_full | Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent |
title_fullStr | Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent |
title_full_unstemmed | Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent |
title_short | Quantitative Estimation of Naproxen in Tablets Using Ibuprofen Sodium as Hydrotropic Agent |
title_sort | quantitative estimation of naproxen in tablets using ibuprofen sodium as hydrotropic agent |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865801/ https://www.ncbi.nlm.nih.gov/pubmed/20490309 http://dx.doi.org/10.4103/0250-474X.56020 |
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