Cargando…
Solid Lipid Nanoparticles: A Modern Formulation Approach in Drug Delivery System
Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the pos...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865805/ https://www.ncbi.nlm.nih.gov/pubmed/20502539 http://dx.doi.org/10.4103/0250-474X.57282 |
_version_ | 1782180875556880384 |
---|---|
author | Mukherjee, S. Ray, S. Thakur, R. S. |
author_facet | Mukherjee, S. Ray, S. Thakur, R. S. |
author_sort | Mukherjee, S. |
collection | PubMed |
description | Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their advantages, limitations and their possible remedies. The different types of nanocarriers which were based on solid lipid like solid lipid nanoparticles, nanostructured lipid carriers, lipid drug conjugates are discussed with their structural differences. Different production methods which are suitable for large scale production and applications of solid lipid nanoparticles are described. Appropriate analytical techniques for characterization of solid lipid nanoparticles like photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry are highlighted. Aspects of solid lipid nanoparticles route of administration and their biodistribution are also incorporated. If appropriately investigated, solid lipid nanoparticles may open new vistas in therapy of complex diseases. |
format | Text |
id | pubmed-2865805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28658052010-05-25 Solid Lipid Nanoparticles: A Modern Formulation Approach in Drug Delivery System Mukherjee, S. Ray, S. Thakur, R. S. Indian J Pharm Sci Review Article Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their advantages, limitations and their possible remedies. The different types of nanocarriers which were based on solid lipid like solid lipid nanoparticles, nanostructured lipid carriers, lipid drug conjugates are discussed with their structural differences. Different production methods which are suitable for large scale production and applications of solid lipid nanoparticles are described. Appropriate analytical techniques for characterization of solid lipid nanoparticles like photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry are highlighted. Aspects of solid lipid nanoparticles route of administration and their biodistribution are also incorporated. If appropriately investigated, solid lipid nanoparticles may open new vistas in therapy of complex diseases. Medknow Publications 2009 /pmc/articles/PMC2865805/ /pubmed/20502539 http://dx.doi.org/10.4103/0250-474X.57282 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Mukherjee, S. Ray, S. Thakur, R. S. Solid Lipid Nanoparticles: A Modern Formulation Approach in Drug Delivery System |
title | Solid Lipid Nanoparticles: A Modern Formulation Approach in Drug Delivery System |
title_full | Solid Lipid Nanoparticles: A Modern Formulation Approach in Drug Delivery System |
title_fullStr | Solid Lipid Nanoparticles: A Modern Formulation Approach in Drug Delivery System |
title_full_unstemmed | Solid Lipid Nanoparticles: A Modern Formulation Approach in Drug Delivery System |
title_short | Solid Lipid Nanoparticles: A Modern Formulation Approach in Drug Delivery System |
title_sort | solid lipid nanoparticles: a modern formulation approach in drug delivery system |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865805/ https://www.ncbi.nlm.nih.gov/pubmed/20502539 http://dx.doi.org/10.4103/0250-474X.57282 |
work_keys_str_mv | AT mukherjees solidlipidnanoparticlesamodernformulationapproachindrugdeliverysystem AT rays solidlipidnanoparticlesamodernformulationapproachindrugdeliverysystem AT thakurrs solidlipidnanoparticlesamodernformulationapproachindrugdeliverysystem |