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Malignant Progression in Two Children with Multiple Osteochondromas

Multiple Osteochondromas (MO) is a disease of benign bony growths with a low incidence of malignant transformation. Secondary chondrosarcoma in children is rare even in children with MO. Making a diagnosis of malignancy in low-grade cartilage tumors is challenging and requires consideration of clini...

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Detalles Bibliográficos
Autores principales: Schmale, Gregory A., Hawkins, Douglas S., Rutledge, Joe, Conrad, Ernest U.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866243/
https://www.ncbi.nlm.nih.gov/pubmed/20467466
http://dx.doi.org/10.1155/2010/417105
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author Schmale, Gregory A.
Hawkins, Douglas S.
Rutledge, Joe
Conrad, Ernest U.
author_facet Schmale, Gregory A.
Hawkins, Douglas S.
Rutledge, Joe
Conrad, Ernest U.
author_sort Schmale, Gregory A.
collection PubMed
description Multiple Osteochondromas (MO) is a disease of benign bony growths with a low incidence of malignant transformation. Secondary chondrosarcoma in children is rare even in children with MO. Making a diagnosis of malignancy in low-grade cartilage tumors is challenging and requires consideration of clinical, radiographic, and histopathological factors. We report two cases of skeletally immature patients with MO who presented with rapidly enlarging and radiographically aggressive lesions consistent with malignant transformation. Both underwent allograft reconstruction of the involved site with no signs of recurrence or metastatic disease at a minimum of four-year follow-up.
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spelling pubmed-28662432010-05-13 Malignant Progression in Two Children with Multiple Osteochondromas Schmale, Gregory A. Hawkins, Douglas S. Rutledge, Joe Conrad, Ernest U. Sarcoma Case Report Multiple Osteochondromas (MO) is a disease of benign bony growths with a low incidence of malignant transformation. Secondary chondrosarcoma in children is rare even in children with MO. Making a diagnosis of malignancy in low-grade cartilage tumors is challenging and requires consideration of clinical, radiographic, and histopathological factors. We report two cases of skeletally immature patients with MO who presented with rapidly enlarging and radiographically aggressive lesions consistent with malignant transformation. Both underwent allograft reconstruction of the involved site with no signs of recurrence or metastatic disease at a minimum of four-year follow-up. Hindawi Publishing Corporation 2010 2010-05-09 /pmc/articles/PMC2866243/ /pubmed/20467466 http://dx.doi.org/10.1155/2010/417105 Text en Copyright © 2010 Gregory A. Schmale et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Schmale, Gregory A.
Hawkins, Douglas S.
Rutledge, Joe
Conrad, Ernest U.
Malignant Progression in Two Children with Multiple Osteochondromas
title Malignant Progression in Two Children with Multiple Osteochondromas
title_full Malignant Progression in Two Children with Multiple Osteochondromas
title_fullStr Malignant Progression in Two Children with Multiple Osteochondromas
title_full_unstemmed Malignant Progression in Two Children with Multiple Osteochondromas
title_short Malignant Progression in Two Children with Multiple Osteochondromas
title_sort malignant progression in two children with multiple osteochondromas
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866243/
https://www.ncbi.nlm.nih.gov/pubmed/20467466
http://dx.doi.org/10.1155/2010/417105
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