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Malignant Progression in Two Children with Multiple Osteochondromas
Multiple Osteochondromas (MO) is a disease of benign bony growths with a low incidence of malignant transformation. Secondary chondrosarcoma in children is rare even in children with MO. Making a diagnosis of malignancy in low-grade cartilage tumors is challenging and requires consideration of clini...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866243/ https://www.ncbi.nlm.nih.gov/pubmed/20467466 http://dx.doi.org/10.1155/2010/417105 |
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author | Schmale, Gregory A. Hawkins, Douglas S. Rutledge, Joe Conrad, Ernest U. |
author_facet | Schmale, Gregory A. Hawkins, Douglas S. Rutledge, Joe Conrad, Ernest U. |
author_sort | Schmale, Gregory A. |
collection | PubMed |
description | Multiple Osteochondromas (MO) is a disease of benign bony growths with a low incidence of malignant transformation. Secondary chondrosarcoma in children is rare even in children with MO. Making a diagnosis of malignancy in low-grade cartilage tumors is challenging and requires consideration of clinical, radiographic, and histopathological factors. We report two cases of skeletally immature patients with MO who presented with rapidly enlarging and radiographically aggressive lesions consistent with malignant transformation. Both underwent allograft reconstruction of the involved site with no signs of recurrence or metastatic disease at a minimum of four-year follow-up. |
format | Text |
id | pubmed-2866243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28662432010-05-13 Malignant Progression in Two Children with Multiple Osteochondromas Schmale, Gregory A. Hawkins, Douglas S. Rutledge, Joe Conrad, Ernest U. Sarcoma Case Report Multiple Osteochondromas (MO) is a disease of benign bony growths with a low incidence of malignant transformation. Secondary chondrosarcoma in children is rare even in children with MO. Making a diagnosis of malignancy in low-grade cartilage tumors is challenging and requires consideration of clinical, radiographic, and histopathological factors. We report two cases of skeletally immature patients with MO who presented with rapidly enlarging and radiographically aggressive lesions consistent with malignant transformation. Both underwent allograft reconstruction of the involved site with no signs of recurrence or metastatic disease at a minimum of four-year follow-up. Hindawi Publishing Corporation 2010 2010-05-09 /pmc/articles/PMC2866243/ /pubmed/20467466 http://dx.doi.org/10.1155/2010/417105 Text en Copyright © 2010 Gregory A. Schmale et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Schmale, Gregory A. Hawkins, Douglas S. Rutledge, Joe Conrad, Ernest U. Malignant Progression in Two Children with Multiple Osteochondromas |
title | Malignant Progression in Two Children with Multiple Osteochondromas |
title_full | Malignant Progression in Two Children with Multiple Osteochondromas |
title_fullStr | Malignant Progression in Two Children with Multiple Osteochondromas |
title_full_unstemmed | Malignant Progression in Two Children with Multiple Osteochondromas |
title_short | Malignant Progression in Two Children with Multiple Osteochondromas |
title_sort | malignant progression in two children with multiple osteochondromas |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866243/ https://www.ncbi.nlm.nih.gov/pubmed/20467466 http://dx.doi.org/10.1155/2010/417105 |
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