IL-17B Can Impact on Endothelial Cellular Traits Linked to Tumour Angiogenesis

IL-17B is a member of the IL-17 cytokine family which have been implicated in inflammatory response and autoimmune diseases such as rheumatoid arthritis. The founding member of this family, IL-17 (or IL-17A), has also been implicated in promoting tumour angiogenesis through the induction of other pr...

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Detalles Bibliográficos
Autores principales: Sanders, Andrew J., Guo, Xiaoxia, Mason, Malcolm D., Jiang, Wen G.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866247/
https://www.ncbi.nlm.nih.gov/pubmed/20467469
http://dx.doi.org/10.1155/2010/817375
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author Sanders, Andrew J.
Guo, Xiaoxia
Mason, Malcolm D.
Jiang, Wen G.
author_facet Sanders, Andrew J.
Guo, Xiaoxia
Mason, Malcolm D.
Jiang, Wen G.
author_sort Sanders, Andrew J.
collection PubMed
description IL-17B is a member of the IL-17 cytokine family which have been implicated in inflammatory response and autoimmune diseases such as rheumatoid arthritis. The founding member of this family, IL-17 (or IL-17A), has also been implicated in promoting tumour angiogenesis through the induction of other proangiogenic factors. Here we examine the potential of recombinant human IL-17B to contribute to the angiogenic process. In vitro rhIL-17B was able to inhibit HECV endothelial cell-matrix adhesion and cellular migration and also, at higher concentrations, could substantially reduce tubule formation compared to untreated HECV cells in a Matrigel tubule formation assay. This data suggests that IL-17B may act in an antiangiogenic manner.
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spelling pubmed-28662472010-05-13 IL-17B Can Impact on Endothelial Cellular Traits Linked to Tumour Angiogenesis Sanders, Andrew J. Guo, Xiaoxia Mason, Malcolm D. Jiang, Wen G. J Oncol Research Article IL-17B is a member of the IL-17 cytokine family which have been implicated in inflammatory response and autoimmune diseases such as rheumatoid arthritis. The founding member of this family, IL-17 (or IL-17A), has also been implicated in promoting tumour angiogenesis through the induction of other proangiogenic factors. Here we examine the potential of recombinant human IL-17B to contribute to the angiogenic process. In vitro rhIL-17B was able to inhibit HECV endothelial cell-matrix adhesion and cellular migration and also, at higher concentrations, could substantially reduce tubule formation compared to untreated HECV cells in a Matrigel tubule formation assay. This data suggests that IL-17B may act in an antiangiogenic manner. Hindawi Publishing Corporation 2010 2010-05-06 /pmc/articles/PMC2866247/ /pubmed/20467469 http://dx.doi.org/10.1155/2010/817375 Text en Copyright © 2010 Andrew J. Sanders et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sanders, Andrew J.
Guo, Xiaoxia
Mason, Malcolm D.
Jiang, Wen G.
IL-17B Can Impact on Endothelial Cellular Traits Linked to Tumour Angiogenesis
title IL-17B Can Impact on Endothelial Cellular Traits Linked to Tumour Angiogenesis
title_full IL-17B Can Impact on Endothelial Cellular Traits Linked to Tumour Angiogenesis
title_fullStr IL-17B Can Impact on Endothelial Cellular Traits Linked to Tumour Angiogenesis
title_full_unstemmed IL-17B Can Impact on Endothelial Cellular Traits Linked to Tumour Angiogenesis
title_short IL-17B Can Impact on Endothelial Cellular Traits Linked to Tumour Angiogenesis
title_sort il-17b can impact on endothelial cellular traits linked to tumour angiogenesis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866247/
https://www.ncbi.nlm.nih.gov/pubmed/20467469
http://dx.doi.org/10.1155/2010/817375
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AT guoxiaoxia il17bcanimpactonendothelialcellulartraitslinkedtotumourangiogenesis
AT masonmalcolmd il17bcanimpactonendothelialcellulartraitslinkedtotumourangiogenesis
AT jiangweng il17bcanimpactonendothelialcellulartraitslinkedtotumourangiogenesis

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