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Protective Effect of Bauhinia purpurea on Gentamicin-induced Nephrotoxicity in Rats
The present study was undertaken to evaluate the ethanol extract of leaves of Bauhinia purpurea and unripe pods of Bauhinia purpurea for its protective effects on gentamicin-induced nephrotoxicity in rats. Nephrotoxicity was induced in Wistar rats by intraperitoneal administration of gentamicin 100...
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866349/ https://www.ncbi.nlm.nih.gov/pubmed/20502576 http://dx.doi.org/10.4103/0250-474X.58196 |
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author | Lakshmi, B. V. S. Neelima, N. Kasthuri, N. Umarani, V. Sudhakar, M. |
author_facet | Lakshmi, B. V. S. Neelima, N. Kasthuri, N. Umarani, V. Sudhakar, M. |
author_sort | Lakshmi, B. V. S. |
collection | PubMed |
description | The present study was undertaken to evaluate the ethanol extract of leaves of Bauhinia purpurea and unripe pods of Bauhinia purpurea for its protective effects on gentamicin-induced nephrotoxicity in rats. Nephrotoxicity was induced in Wistar rats by intraperitoneal administration of gentamicin 100 mg/kg/d for eight days. Effect of concurrent administration of ethanol extract of leaves of Bauhinia purpurea and unripe pods of Bauhinia purpurea at a dose of 300 mg/kg/d given by oral route was determined using serum creatinine, serum uric acid, blood urea nitrogen and serum urea as indicators of kidney damage. The study groups contained six rats in each group. It was observed that the ethanol extract of leaves of Bauhinia purpurea and unripe pods of Bauhinia purpurea significantly protect rat kidneys from gentamicin-induced histopathological changes. Gentamicin-induced glomerular congestion, blood vessel congestion, epithelial desquamation, accumulation of inflammatory cells and necrosis of the kidney cells were found to be reduced in the groups receiving the leaf and unripe pods extract of Bauhinia purpurea along with gentamicin. The extracts also normalized the gentamicin-induced increase in serum creatinine, serum uric acid and blood urea nitrogen levels. This is also evidenced by the histopathological studies. |
format | Text |
id | pubmed-2866349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28663492010-05-25 Protective Effect of Bauhinia purpurea on Gentamicin-induced Nephrotoxicity in Rats Lakshmi, B. V. S. Neelima, N. Kasthuri, N. Umarani, V. Sudhakar, M. Indian J Pharm Sci Short Communication The present study was undertaken to evaluate the ethanol extract of leaves of Bauhinia purpurea and unripe pods of Bauhinia purpurea for its protective effects on gentamicin-induced nephrotoxicity in rats. Nephrotoxicity was induced in Wistar rats by intraperitoneal administration of gentamicin 100 mg/kg/d for eight days. Effect of concurrent administration of ethanol extract of leaves of Bauhinia purpurea and unripe pods of Bauhinia purpurea at a dose of 300 mg/kg/d given by oral route was determined using serum creatinine, serum uric acid, blood urea nitrogen and serum urea as indicators of kidney damage. The study groups contained six rats in each group. It was observed that the ethanol extract of leaves of Bauhinia purpurea and unripe pods of Bauhinia purpurea significantly protect rat kidneys from gentamicin-induced histopathological changes. Gentamicin-induced glomerular congestion, blood vessel congestion, epithelial desquamation, accumulation of inflammatory cells and necrosis of the kidney cells were found to be reduced in the groups receiving the leaf and unripe pods extract of Bauhinia purpurea along with gentamicin. The extracts also normalized the gentamicin-induced increase in serum creatinine, serum uric acid and blood urea nitrogen levels. This is also evidenced by the histopathological studies. Medknow Publications 2009 /pmc/articles/PMC2866349/ /pubmed/20502576 http://dx.doi.org/10.4103/0250-474X.58196 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Lakshmi, B. V. S. Neelima, N. Kasthuri, N. Umarani, V. Sudhakar, M. Protective Effect of Bauhinia purpurea on Gentamicin-induced Nephrotoxicity in Rats |
title | Protective Effect of Bauhinia purpurea on Gentamicin-induced Nephrotoxicity in Rats |
title_full | Protective Effect of Bauhinia purpurea on Gentamicin-induced Nephrotoxicity in Rats |
title_fullStr | Protective Effect of Bauhinia purpurea on Gentamicin-induced Nephrotoxicity in Rats |
title_full_unstemmed | Protective Effect of Bauhinia purpurea on Gentamicin-induced Nephrotoxicity in Rats |
title_short | Protective Effect of Bauhinia purpurea on Gentamicin-induced Nephrotoxicity in Rats |
title_sort | protective effect of bauhinia purpurea on gentamicin-induced nephrotoxicity in rats |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866349/ https://www.ncbi.nlm.nih.gov/pubmed/20502576 http://dx.doi.org/10.4103/0250-474X.58196 |
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