Poor Clinical Sensitivity of Rapid Antigen Test for Influenza A Pandemic (H1N1) 2009 Virus

Influenza A pandemic (H1N1) 2009 virus RNA was detected by reverse transcription–PCR in 144 clinical samples from Bonn, Germany. A common rapid antigen–based test detected the virus in only 11.1% of these samples. The paramount feature of rapid test–positive samples was high virus concentration. Ant...

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Autores principales: Drexler, Jan Felix, Helmer, Angelika, Kirberg, Heike, Reber, Ulrike, Panning, Marcus, Müller, Marcel, Höfling, Katja, Matz, Bertfried, Drosten, Christian, Eis-Hübinger, Anna Maria
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2009
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866420/
https://www.ncbi.nlm.nih.gov/pubmed/19861069
http://dx.doi.org/10.3201/eid1510.091186
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author Drexler, Jan Felix
Helmer, Angelika
Kirberg, Heike
Reber, Ulrike
Panning, Marcus
Müller, Marcel
Höfling, Katja
Matz, Bertfried
Drosten, Christian
Eis-Hübinger, Anna Maria
author_facet Drexler, Jan Felix
Helmer, Angelika
Kirberg, Heike
Reber, Ulrike
Panning, Marcus
Müller, Marcel
Höfling, Katja
Matz, Bertfried
Drosten, Christian
Eis-Hübinger, Anna Maria
author_sort Drexler, Jan Felix
collection PubMed
description Influenza A pandemic (H1N1) 2009 virus RNA was detected by reverse transcription–PCR in 144 clinical samples from Bonn, Germany. A common rapid antigen–based test detected the virus in only 11.1% of these samples. The paramount feature of rapid test–positive samples was high virus concentration. Antigen-based rapid tests appear unsuitable for virologic diagnostics in the current pandemic.
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spelling pubmed-28664202010-05-11 Poor Clinical Sensitivity of Rapid Antigen Test for Influenza A Pandemic (H1N1) 2009 Virus Drexler, Jan Felix Helmer, Angelika Kirberg, Heike Reber, Ulrike Panning, Marcus Müller, Marcel Höfling, Katja Matz, Bertfried Drosten, Christian Eis-Hübinger, Anna Maria Emerg Infect Dis Dispatch Influenza A pandemic (H1N1) 2009 virus RNA was detected by reverse transcription–PCR in 144 clinical samples from Bonn, Germany. A common rapid antigen–based test detected the virus in only 11.1% of these samples. The paramount feature of rapid test–positive samples was high virus concentration. Antigen-based rapid tests appear unsuitable for virologic diagnostics in the current pandemic. Centers for Disease Control and Prevention 2009-10 /pmc/articles/PMC2866420/ /pubmed/19861069 http://dx.doi.org/10.3201/eid1510.091186 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Drexler, Jan Felix
Helmer, Angelika
Kirberg, Heike
Reber, Ulrike
Panning, Marcus
Müller, Marcel
Höfling, Katja
Matz, Bertfried
Drosten, Christian
Eis-Hübinger, Anna Maria
Poor Clinical Sensitivity of Rapid Antigen Test for Influenza A Pandemic (H1N1) 2009 Virus
title Poor Clinical Sensitivity of Rapid Antigen Test for Influenza A Pandemic (H1N1) 2009 Virus
title_full Poor Clinical Sensitivity of Rapid Antigen Test for Influenza A Pandemic (H1N1) 2009 Virus
title_fullStr Poor Clinical Sensitivity of Rapid Antigen Test for Influenza A Pandemic (H1N1) 2009 Virus
title_full_unstemmed Poor Clinical Sensitivity of Rapid Antigen Test for Influenza A Pandemic (H1N1) 2009 Virus
title_short Poor Clinical Sensitivity of Rapid Antigen Test for Influenza A Pandemic (H1N1) 2009 Virus
title_sort poor clinical sensitivity of rapid antigen test for influenza a pandemic (h1n1) 2009 virus
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866420/
https://www.ncbi.nlm.nih.gov/pubmed/19861069
http://dx.doi.org/10.3201/eid1510.091186
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