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Anticancer Effect and Structure-Activity Analysis of Marine Products Isolated from Metabolites of Mangrove Fungi in the South China Sea

Marine-derived fungi provide plenty of structurally unique and biologically active secondary metabolites. We screened 87 marine products from mangrove fungi in the South China Sea for anticancer activity by MTT assay. 14% of the compounds (11/86) exhibited a potent activity against cancer in vitro....

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Autores principales: Tao, Li-yang, Zhang, Jian-ye, Liang, Yong-ju, Chen, Li-ming, Zhen, Li-sheng, Wang, Fang, Mi, Yan-jun, She, Zhi-gang, To, Kenneth Kin Wah, Lin, Yong-cheng, Fu, Li-wu
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866477/
https://www.ncbi.nlm.nih.gov/pubmed/20479969
http://dx.doi.org/10.3390/md8041094
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author Tao, Li-yang
Zhang, Jian-ye
Liang, Yong-ju
Chen, Li-ming
Zhen, Li-sheng
Wang, Fang
Mi, Yan-jun
She, Zhi-gang
To, Kenneth Kin Wah
Lin, Yong-cheng
Fu, Li-wu
author_facet Tao, Li-yang
Zhang, Jian-ye
Liang, Yong-ju
Chen, Li-ming
Zhen, Li-sheng
Wang, Fang
Mi, Yan-jun
She, Zhi-gang
To, Kenneth Kin Wah
Lin, Yong-cheng
Fu, Li-wu
author_sort Tao, Li-yang
collection PubMed
description Marine-derived fungi provide plenty of structurally unique and biologically active secondary metabolites. We screened 87 marine products from mangrove fungi in the South China Sea for anticancer activity by MTT assay. 14% of the compounds (11/86) exhibited a potent activity against cancer in vitro. Importantly, some compounds such as compounds 78 and 81 appeared to be promising for treating cancer patients with multidrug resistance, which should encourage more efforts to isolate promising candidates for further development as clinically useful chemotherapeutic drugs. Furthermore, DNA intercalation was not involved in their anticancer activities, as determined by DNA binding assay. On the other hand, the structure-activity analysis indicated that the hydroxyl group was important for their cytotoxic activity and that bulky functional groups such as phenyl rings could result in a loss of biological activity, which will direct the further development of marine product-based derivatives.
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spelling pubmed-28664772010-05-17 Anticancer Effect and Structure-Activity Analysis of Marine Products Isolated from Metabolites of Mangrove Fungi in the South China Sea Tao, Li-yang Zhang, Jian-ye Liang, Yong-ju Chen, Li-ming Zhen, Li-sheng Wang, Fang Mi, Yan-jun She, Zhi-gang To, Kenneth Kin Wah Lin, Yong-cheng Fu, Li-wu Mar Drugs Article Marine-derived fungi provide plenty of structurally unique and biologically active secondary metabolites. We screened 87 marine products from mangrove fungi in the South China Sea for anticancer activity by MTT assay. 14% of the compounds (11/86) exhibited a potent activity against cancer in vitro. Importantly, some compounds such as compounds 78 and 81 appeared to be promising for treating cancer patients with multidrug resistance, which should encourage more efforts to isolate promising candidates for further development as clinically useful chemotherapeutic drugs. Furthermore, DNA intercalation was not involved in their anticancer activities, as determined by DNA binding assay. On the other hand, the structure-activity analysis indicated that the hydroxyl group was important for their cytotoxic activity and that bulky functional groups such as phenyl rings could result in a loss of biological activity, which will direct the further development of marine product-based derivatives. Molecular Diversity Preservation International 2010-04-01 /pmc/articles/PMC2866477/ /pubmed/20479969 http://dx.doi.org/10.3390/md8041094 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Tao, Li-yang
Zhang, Jian-ye
Liang, Yong-ju
Chen, Li-ming
Zhen, Li-sheng
Wang, Fang
Mi, Yan-jun
She, Zhi-gang
To, Kenneth Kin Wah
Lin, Yong-cheng
Fu, Li-wu
Anticancer Effect and Structure-Activity Analysis of Marine Products Isolated from Metabolites of Mangrove Fungi in the South China Sea
title Anticancer Effect and Structure-Activity Analysis of Marine Products Isolated from Metabolites of Mangrove Fungi in the South China Sea
title_full Anticancer Effect and Structure-Activity Analysis of Marine Products Isolated from Metabolites of Mangrove Fungi in the South China Sea
title_fullStr Anticancer Effect and Structure-Activity Analysis of Marine Products Isolated from Metabolites of Mangrove Fungi in the South China Sea
title_full_unstemmed Anticancer Effect and Structure-Activity Analysis of Marine Products Isolated from Metabolites of Mangrove Fungi in the South China Sea
title_short Anticancer Effect and Structure-Activity Analysis of Marine Products Isolated from Metabolites of Mangrove Fungi in the South China Sea
title_sort anticancer effect and structure-activity analysis of marine products isolated from metabolites of mangrove fungi in the south china sea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866477/
https://www.ncbi.nlm.nih.gov/pubmed/20479969
http://dx.doi.org/10.3390/md8041094
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