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Carrageenans as a New Source of Drugs with Metal Binding Properties

Carrageenans are abundant and safe non-starch polysaccharides exerting their biological effects in living organisms. Apart from their known pro-inflammation properties and some pharmacological activity, carrageenans can also strongly bind and hold metal ions. This property can be used for creation o...

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Autores principales: Khotimchenko, Yuri S., Khozhaenko, Elena V., Khotimchenko, Maxim Y., Kolenchenko, Elena A., Kovalev, Valeri V.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866478/
https://www.ncbi.nlm.nih.gov/pubmed/20479970
http://dx.doi.org/10.3390/md8041106
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author Khotimchenko, Yuri S.
Khozhaenko, Elena V.
Khotimchenko, Maxim Y.
Kolenchenko, Elena A.
Kovalev, Valeri V.
author_facet Khotimchenko, Yuri S.
Khozhaenko, Elena V.
Khotimchenko, Maxim Y.
Kolenchenko, Elena A.
Kovalev, Valeri V.
author_sort Khotimchenko, Yuri S.
collection PubMed
description Carrageenans are abundant and safe non-starch polysaccharides exerting their biological effects in living organisms. Apart from their known pro-inflammation properties and some pharmacological activity, carrageenans can also strongly bind and hold metal ions. This property can be used for creation of the new drugs for elimination of metals from the body or targeted delivery of these metal ions for healing purposes. Metal binding activity of different carrageenans in aqueous solutions containing Y(3+) or Pb(2+) ions was studied in a batch sorption system. The metal uptake by carrageenans is not affected by the change of the pH within the range from 2.0 to 6.0. The rates and binding capacities of carrageenans regarding metal ions were evaluated. The Langmuir, Freundlich and BET sorption models were applied to describe the isotherms and constants, and the sorption isothermal data could be explained well by the Langmuir equation. The results obtained through the study suggest that κ-, ι-, and λ-carrageenans are favorable sorbents. The largest amount of Y(3+) and Pb(2+) ions are bound by ι-carrageenan. Therefore, it can be concluded that this type of polysaccharide is the more appropriate substance for elaboration of the drugs with high selective metal binding properties.
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spelling pubmed-28664782010-05-17 Carrageenans as a New Source of Drugs with Metal Binding Properties Khotimchenko, Yuri S. Khozhaenko, Elena V. Khotimchenko, Maxim Y. Kolenchenko, Elena A. Kovalev, Valeri V. Mar Drugs Article Carrageenans are abundant and safe non-starch polysaccharides exerting their biological effects in living organisms. Apart from their known pro-inflammation properties and some pharmacological activity, carrageenans can also strongly bind and hold metal ions. This property can be used for creation of the new drugs for elimination of metals from the body or targeted delivery of these metal ions for healing purposes. Metal binding activity of different carrageenans in aqueous solutions containing Y(3+) or Pb(2+) ions was studied in a batch sorption system. The metal uptake by carrageenans is not affected by the change of the pH within the range from 2.0 to 6.0. The rates and binding capacities of carrageenans regarding metal ions were evaluated. The Langmuir, Freundlich and BET sorption models were applied to describe the isotherms and constants, and the sorption isothermal data could be explained well by the Langmuir equation. The results obtained through the study suggest that κ-, ι-, and λ-carrageenans are favorable sorbents. The largest amount of Y(3+) and Pb(2+) ions are bound by ι-carrageenan. Therefore, it can be concluded that this type of polysaccharide is the more appropriate substance for elaboration of the drugs with high selective metal binding properties. Molecular Diversity Preservation International 2010-04-01 /pmc/articles/PMC2866478/ /pubmed/20479970 http://dx.doi.org/10.3390/md8041106 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Khotimchenko, Yuri S.
Khozhaenko, Elena V.
Khotimchenko, Maxim Y.
Kolenchenko, Elena A.
Kovalev, Valeri V.
Carrageenans as a New Source of Drugs with Metal Binding Properties
title Carrageenans as a New Source of Drugs with Metal Binding Properties
title_full Carrageenans as a New Source of Drugs with Metal Binding Properties
title_fullStr Carrageenans as a New Source of Drugs with Metal Binding Properties
title_full_unstemmed Carrageenans as a New Source of Drugs with Metal Binding Properties
title_short Carrageenans as a New Source of Drugs with Metal Binding Properties
title_sort carrageenans as a new source of drugs with metal binding properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866478/
https://www.ncbi.nlm.nih.gov/pubmed/20479970
http://dx.doi.org/10.3390/md8041106
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