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The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds

Lobophora variegata, a brown alga collected from the coast of the Yucatan peninsula, Mexico, was studied for antiprotozoal activity against Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. The whole extract showed the highest activity against T. vaginalis, with an IC(50) value...

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Autores principales: Cantillo-Ciau, Zulema, Moo-Puc, Rosa, Quijano, Leovigildo, Freile-Pelegrín, Yolanda
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866487/
https://www.ncbi.nlm.nih.gov/pubmed/20479979
http://dx.doi.org/10.3390/md8041292
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author Cantillo-Ciau, Zulema
Moo-Puc, Rosa
Quijano, Leovigildo
Freile-Pelegrín, Yolanda
author_facet Cantillo-Ciau, Zulema
Moo-Puc, Rosa
Quijano, Leovigildo
Freile-Pelegrín, Yolanda
author_sort Cantillo-Ciau, Zulema
collection PubMed
description Lobophora variegata, a brown alga collected from the coast of the Yucatan peninsula, Mexico, was studied for antiprotozoal activity against Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. The whole extract showed the highest activity against T. vaginalis, with an IC(50) value of 3.2 μg/mL. For the fractions, the best antiprotozoal activity was found in non-polar fractions. The chloroform fraction of the extract contained a major sulfoquinovosyldiacylglycerol (SQDG), identified as 1-O-palmitoyl-2-O-myristoyl-3-O-(6‴-sulfo-α-d-quinovopyranosyl)-glycerol (1), together with small amounts of 1,2-di-O-palmitoyl-3-O-(6‴-sulfo-α-d-quinovopyranosyl)-glycerol (2) and a new compound identified as 1-O-palmitoyl-2-O-oleoyl-3-O-(6‴-sulfo-α-d-quinovopyranosyl)-glycerol (3). Their structures were elucidated on the basis of chemical and enzymatic hydrolysis and careful analysis of FAB-MS and NMR spectroscopic data. This is the first report on the isolation of SQDGs from L. variegata. The mixture of 1–3 showed good activity against E. histolytica and moderate activity against T. vaginalis with IC(50s) of 3.9 and 8.0 μg/mL, respectively, however, the activity of 1–3 is not as effective as metronidazole. These results afford ground information for the potential use of the whole extract and fractions of this species in protozoal infections.
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spelling pubmed-28664872010-05-17 The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds Cantillo-Ciau, Zulema Moo-Puc, Rosa Quijano, Leovigildo Freile-Pelegrín, Yolanda Mar Drugs Article Lobophora variegata, a brown alga collected from the coast of the Yucatan peninsula, Mexico, was studied for antiprotozoal activity against Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. The whole extract showed the highest activity against T. vaginalis, with an IC(50) value of 3.2 μg/mL. For the fractions, the best antiprotozoal activity was found in non-polar fractions. The chloroform fraction of the extract contained a major sulfoquinovosyldiacylglycerol (SQDG), identified as 1-O-palmitoyl-2-O-myristoyl-3-O-(6‴-sulfo-α-d-quinovopyranosyl)-glycerol (1), together with small amounts of 1,2-di-O-palmitoyl-3-O-(6‴-sulfo-α-d-quinovopyranosyl)-glycerol (2) and a new compound identified as 1-O-palmitoyl-2-O-oleoyl-3-O-(6‴-sulfo-α-d-quinovopyranosyl)-glycerol (3). Their structures were elucidated on the basis of chemical and enzymatic hydrolysis and careful analysis of FAB-MS and NMR spectroscopic data. This is the first report on the isolation of SQDGs from L. variegata. The mixture of 1–3 showed good activity against E. histolytica and moderate activity against T. vaginalis with IC(50s) of 3.9 and 8.0 μg/mL, respectively, however, the activity of 1–3 is not as effective as metronidazole. These results afford ground information for the potential use of the whole extract and fractions of this species in protozoal infections. Molecular Diversity Preservation International 2010-04-16 /pmc/articles/PMC2866487/ /pubmed/20479979 http://dx.doi.org/10.3390/md8041292 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Cantillo-Ciau, Zulema
Moo-Puc, Rosa
Quijano, Leovigildo
Freile-Pelegrín, Yolanda
The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds
title The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds
title_full The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds
title_fullStr The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds
title_full_unstemmed The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds
title_short The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds
title_sort tropical brown alga lobophora variegata: a source of antiprotozoal compounds
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866487/
https://www.ncbi.nlm.nih.gov/pubmed/20479979
http://dx.doi.org/10.3390/md8041292
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