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The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds
Lobophora variegata, a brown alga collected from the coast of the Yucatan peninsula, Mexico, was studied for antiprotozoal activity against Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. The whole extract showed the highest activity against T. vaginalis, with an IC(50) value...
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Formato: | Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866487/ https://www.ncbi.nlm.nih.gov/pubmed/20479979 http://dx.doi.org/10.3390/md8041292 |
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author | Cantillo-Ciau, Zulema Moo-Puc, Rosa Quijano, Leovigildo Freile-Pelegrín, Yolanda |
author_facet | Cantillo-Ciau, Zulema Moo-Puc, Rosa Quijano, Leovigildo Freile-Pelegrín, Yolanda |
author_sort | Cantillo-Ciau, Zulema |
collection | PubMed |
description | Lobophora variegata, a brown alga collected from the coast of the Yucatan peninsula, Mexico, was studied for antiprotozoal activity against Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. The whole extract showed the highest activity against T. vaginalis, with an IC(50) value of 3.2 μg/mL. For the fractions, the best antiprotozoal activity was found in non-polar fractions. The chloroform fraction of the extract contained a major sulfoquinovosyldiacylglycerol (SQDG), identified as 1-O-palmitoyl-2-O-myristoyl-3-O-(6‴-sulfo-α-d-quinovopyranosyl)-glycerol (1), together with small amounts of 1,2-di-O-palmitoyl-3-O-(6‴-sulfo-α-d-quinovopyranosyl)-glycerol (2) and a new compound identified as 1-O-palmitoyl-2-O-oleoyl-3-O-(6‴-sulfo-α-d-quinovopyranosyl)-glycerol (3). Their structures were elucidated on the basis of chemical and enzymatic hydrolysis and careful analysis of FAB-MS and NMR spectroscopic data. This is the first report on the isolation of SQDGs from L. variegata. The mixture of 1–3 showed good activity against E. histolytica and moderate activity against T. vaginalis with IC(50s) of 3.9 and 8.0 μg/mL, respectively, however, the activity of 1–3 is not as effective as metronidazole. These results afford ground information for the potential use of the whole extract and fractions of this species in protozoal infections. |
format | Text |
id | pubmed-2866487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Molecular Diversity Preservation International |
record_format | MEDLINE/PubMed |
spelling | pubmed-28664872010-05-17 The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds Cantillo-Ciau, Zulema Moo-Puc, Rosa Quijano, Leovigildo Freile-Pelegrín, Yolanda Mar Drugs Article Lobophora variegata, a brown alga collected from the coast of the Yucatan peninsula, Mexico, was studied for antiprotozoal activity against Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. The whole extract showed the highest activity against T. vaginalis, with an IC(50) value of 3.2 μg/mL. For the fractions, the best antiprotozoal activity was found in non-polar fractions. The chloroform fraction of the extract contained a major sulfoquinovosyldiacylglycerol (SQDG), identified as 1-O-palmitoyl-2-O-myristoyl-3-O-(6‴-sulfo-α-d-quinovopyranosyl)-glycerol (1), together with small amounts of 1,2-di-O-palmitoyl-3-O-(6‴-sulfo-α-d-quinovopyranosyl)-glycerol (2) and a new compound identified as 1-O-palmitoyl-2-O-oleoyl-3-O-(6‴-sulfo-α-d-quinovopyranosyl)-glycerol (3). Their structures were elucidated on the basis of chemical and enzymatic hydrolysis and careful analysis of FAB-MS and NMR spectroscopic data. This is the first report on the isolation of SQDGs from L. variegata. The mixture of 1–3 showed good activity against E. histolytica and moderate activity against T. vaginalis with IC(50s) of 3.9 and 8.0 μg/mL, respectively, however, the activity of 1–3 is not as effective as metronidazole. These results afford ground information for the potential use of the whole extract and fractions of this species in protozoal infections. Molecular Diversity Preservation International 2010-04-16 /pmc/articles/PMC2866487/ /pubmed/20479979 http://dx.doi.org/10.3390/md8041292 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Cantillo-Ciau, Zulema Moo-Puc, Rosa Quijano, Leovigildo Freile-Pelegrín, Yolanda The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds |
title | The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds |
title_full | The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds |
title_fullStr | The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds |
title_full_unstemmed | The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds |
title_short | The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds |
title_sort | tropical brown alga lobophora variegata: a source of antiprotozoal compounds |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866487/ https://www.ncbi.nlm.nih.gov/pubmed/20479979 http://dx.doi.org/10.3390/md8041292 |
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