Cargando…

Effect of Intermittent Versus Continuous Parathyroid Hormone in the Cardiovascular System of Rats

OBJECTIVE: PTH increases ionic calcium concentration in the serum, acting primarily on bone and kidney cells through the type 1 PTH receptor. Interestingly, PTH stimulates bone formation when administrated intermittently but causes severe bone loss with continuous administration. Daily injections of...

Descripción completa

Detalles Bibliográficos
Autores principales: Smajilovic, Sanela, Schaal-Jensen, Rasmus, Jabbari, Reza, Smajilovic, Una, Haunso, Stig, Tfelt-Hansen, Jacob
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866532/
https://www.ncbi.nlm.nih.gov/pubmed/20461233
http://dx.doi.org/10.2174/1874192401004010110
_version_ 1782180922572931072
author Smajilovic, Sanela
Schaal-Jensen, Rasmus
Jabbari, Reza
Smajilovic, Una
Haunso, Stig
Tfelt-Hansen, Jacob
author_facet Smajilovic, Sanela
Schaal-Jensen, Rasmus
Jabbari, Reza
Smajilovic, Una
Haunso, Stig
Tfelt-Hansen, Jacob
author_sort Smajilovic, Sanela
collection PubMed
description OBJECTIVE: PTH increases ionic calcium concentration in the serum, acting primarily on bone and kidney cells through the type 1 PTH receptor. Interestingly, PTH stimulates bone formation when administrated intermittently but causes severe bone loss with continuous administration. Daily injections of PTH are used as the most promising anabolic agent in the treatment of severe osteoporosis. Elevated PTH is reported an independent risk factor for left ventricle hypertrophy. DESIGN: in rats we investigated the effect of intermittent and continuous administration of PTH on blood pressure, heart rate and development of cardiac hypertrophy and fibrosis. RESULTS: We did not find PTH to induce heart hypertrophy. In contrast, continuous administration of PTH the mRNA level of a hypertrophic marker gene, atrial natriuretic peptide. When comparing the effect of continuously versus injected PTH collagen 1 mRNA was significantly higher in continuously treated animals. CONCLUSION: our data demonstrated a decrease in heart rate upon continuous administration of PTH in rats. No changes in blood pressure were observed. Moreover, neither intermittent nor continuous administration of PTH induced ventricular hypertrophy. But continuous PTH induced a marker of collagen 1. Thus, these data did not reveal any negative effects of the injection of PTH on the cardiovascular system.
format Text
id pubmed-2866532
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Bentham Open
record_format MEDLINE/PubMed
spelling pubmed-28665322010-05-11 Effect of Intermittent Versus Continuous Parathyroid Hormone in the Cardiovascular System of Rats Smajilovic, Sanela Schaal-Jensen, Rasmus Jabbari, Reza Smajilovic, Una Haunso, Stig Tfelt-Hansen, Jacob Open Cardiovasc Med J Article OBJECTIVE: PTH increases ionic calcium concentration in the serum, acting primarily on bone and kidney cells through the type 1 PTH receptor. Interestingly, PTH stimulates bone formation when administrated intermittently but causes severe bone loss with continuous administration. Daily injections of PTH are used as the most promising anabolic agent in the treatment of severe osteoporosis. Elevated PTH is reported an independent risk factor for left ventricle hypertrophy. DESIGN: in rats we investigated the effect of intermittent and continuous administration of PTH on blood pressure, heart rate and development of cardiac hypertrophy and fibrosis. RESULTS: We did not find PTH to induce heart hypertrophy. In contrast, continuous administration of PTH the mRNA level of a hypertrophic marker gene, atrial natriuretic peptide. When comparing the effect of continuously versus injected PTH collagen 1 mRNA was significantly higher in continuously treated animals. CONCLUSION: our data demonstrated a decrease in heart rate upon continuous administration of PTH in rats. No changes in blood pressure were observed. Moreover, neither intermittent nor continuous administration of PTH induced ventricular hypertrophy. But continuous PTH induced a marker of collagen 1. Thus, these data did not reveal any negative effects of the injection of PTH on the cardiovascular system. Bentham Open 2010-03-31 /pmc/articles/PMC2866532/ /pubmed/20461233 http://dx.doi.org/10.2174/1874192401004010110 Text en © Smajilovic et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Smajilovic, Sanela
Schaal-Jensen, Rasmus
Jabbari, Reza
Smajilovic, Una
Haunso, Stig
Tfelt-Hansen, Jacob
Effect of Intermittent Versus Continuous Parathyroid Hormone in the Cardiovascular System of Rats
title Effect of Intermittent Versus Continuous Parathyroid Hormone in the Cardiovascular System of Rats
title_full Effect of Intermittent Versus Continuous Parathyroid Hormone in the Cardiovascular System of Rats
title_fullStr Effect of Intermittent Versus Continuous Parathyroid Hormone in the Cardiovascular System of Rats
title_full_unstemmed Effect of Intermittent Versus Continuous Parathyroid Hormone in the Cardiovascular System of Rats
title_short Effect of Intermittent Versus Continuous Parathyroid Hormone in the Cardiovascular System of Rats
title_sort effect of intermittent versus continuous parathyroid hormone in the cardiovascular system of rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866532/
https://www.ncbi.nlm.nih.gov/pubmed/20461233
http://dx.doi.org/10.2174/1874192401004010110
work_keys_str_mv AT smajilovicsanela effectofintermittentversuscontinuousparathyroidhormoneinthecardiovascularsystemofrats
AT schaaljensenrasmus effectofintermittentversuscontinuousparathyroidhormoneinthecardiovascularsystemofrats
AT jabbarireza effectofintermittentversuscontinuousparathyroidhormoneinthecardiovascularsystemofrats
AT smajilovicuna effectofintermittentversuscontinuousparathyroidhormoneinthecardiovascularsystemofrats
AT haunsostig effectofintermittentversuscontinuousparathyroidhormoneinthecardiovascularsystemofrats
AT tfelthansenjacob effectofintermittentversuscontinuousparathyroidhormoneinthecardiovascularsystemofrats