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Clinical relevance of maximal inspiratory pressure: determination in COPD exacerbation
Muscle dysfunction represents a pathophysiological feature of chronic obstructive pulmonary disease (COPD). Muscle impairment contributes to decreased effort capacity in these patients at least in the same proportion as pulmonary function limitation. Maximal inspiratory pressure (MIP) is a reliable,...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866561/ https://www.ncbi.nlm.nih.gov/pubmed/20461143 |
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author | Tudorache, Voicu Oancea, Cristian Mlădinescu, Ovidiu Fira |
author_facet | Tudorache, Voicu Oancea, Cristian Mlădinescu, Ovidiu Fira |
author_sort | Tudorache, Voicu |
collection | PubMed |
description | Muscle dysfunction represents a pathophysiological feature of chronic obstructive pulmonary disease (COPD). Muscle impairment contributes to decreased effort capacity in these patients at least in the same proportion as pulmonary function limitation. Maximal inspiratory pressure (MIP) is a reliable, noninvasive parameter for assessing the respiratory muscle capacity. The aim of the present study was to determine the role of MIP in effort capacity decrease in COPD patients. MIP was measured in 121 COPD patients without hyperinflation (RV < 150%) together with the following investigations: body plethysmography, body impedance analysis, dynamometry, 6-minute walking test (6MWT), determination of SaO(2) and serum levels of highly sensitive C-reactive protein (hsCRP). MIP (kPa) was significantly decreased in moderate-severe stages (6.19 ± 2.42, COPD II; 5.35 ± 2.49, COPD III; 4.56 ± 1.98, COPD IV vs 7.90 ± 2.61 in controls, P < 0.001), whereas the muscle force assessed by dynamometry was decreased only in advanced stages of disease (0.47 ± 0.12, COPD III; 0.41 ± 0.07, COPD IV vs 0.71 ± 0.16 in controls, P < 0.001). The values of MIP correlated (r = 0.53, P = 0.0003) with the distance walked in 6MWT. MIP may provide additive information concerning the general profile of muscle dysfunction in COPD patients. |
format | Text |
id | pubmed-2866561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-28665612010-05-11 Clinical relevance of maximal inspiratory pressure: determination in COPD exacerbation Tudorache, Voicu Oancea, Cristian Mlădinescu, Ovidiu Fira Int J Chron Obstruct Pulmon Dis Original Research Muscle dysfunction represents a pathophysiological feature of chronic obstructive pulmonary disease (COPD). Muscle impairment contributes to decreased effort capacity in these patients at least in the same proportion as pulmonary function limitation. Maximal inspiratory pressure (MIP) is a reliable, noninvasive parameter for assessing the respiratory muscle capacity. The aim of the present study was to determine the role of MIP in effort capacity decrease in COPD patients. MIP was measured in 121 COPD patients without hyperinflation (RV < 150%) together with the following investigations: body plethysmography, body impedance analysis, dynamometry, 6-minute walking test (6MWT), determination of SaO(2) and serum levels of highly sensitive C-reactive protein (hsCRP). MIP (kPa) was significantly decreased in moderate-severe stages (6.19 ± 2.42, COPD II; 5.35 ± 2.49, COPD III; 4.56 ± 1.98, COPD IV vs 7.90 ± 2.61 in controls, P < 0.001), whereas the muscle force assessed by dynamometry was decreased only in advanced stages of disease (0.47 ± 0.12, COPD III; 0.41 ± 0.07, COPD IV vs 0.71 ± 0.16 in controls, P < 0.001). The values of MIP correlated (r = 0.53, P = 0.0003) with the distance walked in 6MWT. MIP may provide additive information concerning the general profile of muscle dysfunction in COPD patients. Dove Medical Press 2010-05-06 2010 /pmc/articles/PMC2866561/ /pubmed/20461143 Text en © 2010 Tudorache et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Tudorache, Voicu Oancea, Cristian Mlădinescu, Ovidiu Fira Clinical relevance of maximal inspiratory pressure: determination in COPD exacerbation |
title | Clinical relevance of maximal inspiratory pressure: determination in COPD exacerbation |
title_full | Clinical relevance of maximal inspiratory pressure: determination in COPD exacerbation |
title_fullStr | Clinical relevance of maximal inspiratory pressure: determination in COPD exacerbation |
title_full_unstemmed | Clinical relevance of maximal inspiratory pressure: determination in COPD exacerbation |
title_short | Clinical relevance of maximal inspiratory pressure: determination in COPD exacerbation |
title_sort | clinical relevance of maximal inspiratory pressure: determination in copd exacerbation |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866561/ https://www.ncbi.nlm.nih.gov/pubmed/20461143 |
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