MicroRNA-29b Regulates the Expression Level of Human Progranulin, a Secreted Glycoprotein Implicated in Frontotemporal Dementia

Progranulin deficiency is thought to cause some forms of frontotemporal dementia (FTD), a major early-onset age-dependent neurodegenerative disease. How progranulin (PGRN) expression is regulated is largely unknown. We identified an evolutionarily conserved binding site for microRNA-29b (miR-29b) in...

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Detalles Bibliográficos
Autores principales: Jiao, Jian, Herl, Lauren D., Farese, Robert V., Gao, Fen-Biao
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866661/
https://www.ncbi.nlm.nih.gov/pubmed/20479936
http://dx.doi.org/10.1371/journal.pone.0010551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866661/
https://www.ncbi.nlm.nih.gov/pubmed/20479936
http://dx.doi.org/10.1371/journal.pone.0010551

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