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Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort

BACKGROUND: Few studies have used longitudinal ultrasound measurements to assess the effect of traffic-related air pollution on fetal growth. OBJECTIVE: We examined the relationship between exposure to nitrogen dioxide (NO(2)) and aromatic hydrocarbons [benzene, toluene, ethylbenzene, m/p-xylene, an...

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Autores principales: Aguilera, Inmaculada, Garcia-Esteban, Raquel, Iñiguez, Carmen, Nieuwenhuijsen, Mark J., Rodríguez, Àgueda, Paez, Montserrat, Ballester, Ferran, Sunyer, Jordi
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866689/
https://www.ncbi.nlm.nih.gov/pubmed/20103496
http://dx.doi.org/10.1289/ehp.0901228
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author Aguilera, Inmaculada
Garcia-Esteban, Raquel
Iñiguez, Carmen
Nieuwenhuijsen, Mark J.
Rodríguez, Àgueda
Paez, Montserrat
Ballester, Ferran
Sunyer, Jordi
author_facet Aguilera, Inmaculada
Garcia-Esteban, Raquel
Iñiguez, Carmen
Nieuwenhuijsen, Mark J.
Rodríguez, Àgueda
Paez, Montserrat
Ballester, Ferran
Sunyer, Jordi
author_sort Aguilera, Inmaculada
collection PubMed
description BACKGROUND: Few studies have used longitudinal ultrasound measurements to assess the effect of traffic-related air pollution on fetal growth. OBJECTIVE: We examined the relationship between exposure to nitrogen dioxide (NO(2)) and aromatic hydrocarbons [benzene, toluene, ethylbenzene, m/p-xylene, and o-xylene (BTEX)] on fetal growth assessed by 1,692 ultrasound measurements among 562 pregnant women from the Sabadell cohort of the Spanish INMA (Environment and Childhood) study. METHODS: We used temporally adjusted land-use regression models to estimate exposures to NO(2) and BTEX. We fitted mixed-effects models to estimate longitudinal growth curves for femur length (FL), head circumference (HC), abdominal circumference (AC), biparietal diameter (BPD), and estimated fetal weight (EFW). Unconditional and conditional SD scores were calculated at 12, 20, and 32 weeks of gestation. Sensitivity analyses were performed considering time–activity patterns during pregnancy. RESULTS: Exposure to BTEX from early pregnancy was negatively associated with growth in BPD during weeks 20–32. None of the other fetal growth parameters were associated with exposure to air pollution during pregnancy. When considering only women who spent < 2 hr/day in nonresidential outdoor locations, effect estimates were stronger and statistically significant for the association between NO(2) and growth in HC during weeks 12–20 and growth in AC, BPD, and EFW during weeks 20–32. CONCLUSIONS: Our results lend some support to an effect of exposure to traffic-related air pollutants from early pregnancy on fetal growth during mid-pregnancy.
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spelling pubmed-28666892010-05-26 Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort Aguilera, Inmaculada Garcia-Esteban, Raquel Iñiguez, Carmen Nieuwenhuijsen, Mark J. Rodríguez, Àgueda Paez, Montserrat Ballester, Ferran Sunyer, Jordi Environ Health Perspect Research BACKGROUND: Few studies have used longitudinal ultrasound measurements to assess the effect of traffic-related air pollution on fetal growth. OBJECTIVE: We examined the relationship between exposure to nitrogen dioxide (NO(2)) and aromatic hydrocarbons [benzene, toluene, ethylbenzene, m/p-xylene, and o-xylene (BTEX)] on fetal growth assessed by 1,692 ultrasound measurements among 562 pregnant women from the Sabadell cohort of the Spanish INMA (Environment and Childhood) study. METHODS: We used temporally adjusted land-use regression models to estimate exposures to NO(2) and BTEX. We fitted mixed-effects models to estimate longitudinal growth curves for femur length (FL), head circumference (HC), abdominal circumference (AC), biparietal diameter (BPD), and estimated fetal weight (EFW). Unconditional and conditional SD scores were calculated at 12, 20, and 32 weeks of gestation. Sensitivity analyses were performed considering time–activity patterns during pregnancy. RESULTS: Exposure to BTEX from early pregnancy was negatively associated with growth in BPD during weeks 20–32. None of the other fetal growth parameters were associated with exposure to air pollution during pregnancy. When considering only women who spent < 2 hr/day in nonresidential outdoor locations, effect estimates were stronger and statistically significant for the association between NO(2) and growth in HC during weeks 12–20 and growth in AC, BPD, and EFW during weeks 20–32. CONCLUSIONS: Our results lend some support to an effect of exposure to traffic-related air pollutants from early pregnancy on fetal growth during mid-pregnancy. National Institute of Environmental Health Sciences 2010-05 2010-01-26 /pmc/articles/PMC2866689/ /pubmed/20103496 http://dx.doi.org/10.1289/ehp.0901228 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Aguilera, Inmaculada
Garcia-Esteban, Raquel
Iñiguez, Carmen
Nieuwenhuijsen, Mark J.
Rodríguez, Àgueda
Paez, Montserrat
Ballester, Ferran
Sunyer, Jordi
Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort
title Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort
title_full Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort
title_fullStr Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort
title_full_unstemmed Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort
title_short Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort
title_sort prenatal exposure to traffic-related air pollution and ultrasound measures of fetal growth in the inma sabadell cohort
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866689/
https://www.ncbi.nlm.nih.gov/pubmed/20103496
http://dx.doi.org/10.1289/ehp.0901228
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