Regulation of RhoGTPase crosstalk, degradation and activity by RhoGDI1

At steady state, most Rho GTPases are bound in the cytosol to Rho Guanine nucleotide Dissociation Inhibitors (RhoGDI) 1. RhoGDIs have generally been considered to passively hold Rho proteins in an inactive state within the cytoplasm. Here we describe an evolutionarily conserved mechanism by which Rh...

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Detalles Bibliográficos
Autores principales: Boulter, Etienne, Garcia-Mata, Rafael, Guilluy, Christophe, Dubash, Adi, Rossi, Guendalina, Brennwald, Patrick J., Burridge, Keith
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866742/
https://www.ncbi.nlm.nih.gov/pubmed/20400958
http://dx.doi.org/10.1038/ncb2049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866742/
https://www.ncbi.nlm.nih.gov/pubmed/20400958
http://dx.doi.org/10.1038/ncb2049

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