The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma

Peripheral T cell lymphomas (PTCLs) are highly aggressive malignancies with poor prognosis. Their molecular pathogenesis is not well understood and small animal models for the disease are lacking. Recently, the chromosomal translocation t(5;9)(q33;q22) generating the interleukin-2 (IL-2)–inducible T...

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Detalles Bibliográficos
Autores principales: Pechloff, Konstanze, Holch, Julian, Ferch, Uta, Schweneker, Marc, Brunner, Kristina, Kremer, Markus, Sparwasser, Tim, Quintanilla-Martinez, Leticia, Zimber-Strobl, Ursula, Streubel, Berthold, Gewies, Andreas, Peschel, Christian, Ruland, Jürgen
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867290/
https://www.ncbi.nlm.nih.gov/pubmed/20439541
http://dx.doi.org/10.1084/jem.20092042

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