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Antimicrobial resistance of H. pylori to the outcome of 10-days vs. 7-days Moxifloxacin based therapy for the eradication: a randomized controlled trial

INTRODUCTION: Antibiotic resistance decreases success of Helicobacter pylori (Hp) eradication. Recently published results show low rate of resistance and better compliance with moxifloxacin based regiments. AIMS&METHODS: Whether 7 days moxifloxacin with lansoprasole and amoxycillin can be compar...

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Autores principales: Bago, Josip, Majstorović, Karolina, Belošić-Halle, Željka, Kućišec, Nastja, Bakula, Vinko, Tomić, Monika, Bago, Petra, Troskot, Rosana
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867970/
https://www.ncbi.nlm.nih.gov/pubmed/20398300
http://dx.doi.org/10.1186/1476-0711-9-13
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author Bago, Josip
Majstorović, Karolina
Belošić-Halle, Željka
Kućišec, Nastja
Bakula, Vinko
Tomić, Monika
Bago, Petra
Troskot, Rosana
author_facet Bago, Josip
Majstorović, Karolina
Belošić-Halle, Željka
Kućišec, Nastja
Bakula, Vinko
Tomić, Monika
Bago, Petra
Troskot, Rosana
author_sort Bago, Josip
collection PubMed
description INTRODUCTION: Antibiotic resistance decreases success of Helicobacter pylori (Hp) eradication. Recently published results show low rate of resistance and better compliance with moxifloxacin based regiments. AIMS&METHODS: Whether 7 days moxifloxacin with lansoprasole and amoxycillin can be compared with 10 days moxifloxacin with lansoprasole and amoxycillin according to moxifloxacin resistance. Patients with non-ulcer dyspepsia who had culture and histology positive Hp infection (n = 150) were randomly assigned into two groups. The first group (n = 75) received moxifloxacin 400 mg/d during 7 days and the other (n = 75) received moxifloxacin 400 mg/d during 10 days. All patients received amoxycillin 1 g twice daily, lansoprasole 30 mg twice daily. All Hp cultures were tested for sensitivity to moxifloxacin. RESULTS: 138 patients (92%) completed the study, 68 in the first group and 70 in the second. Eradication rates were 84% (57/68) and 76% (57/75) in the 7 days moxifloxacin group and 90% and 84% in the second group (63/70, 63/75) according to the PP and ITT analysis; p = n.s. Among 129 patients (86% of study group), 6% of strains were primary resistant to moxifloxacin. Eradication of moxifloxacin sensitive/resistant strains was 98%/66%, p < 0.05 CONCLUSION: According to our results we recommend 7 days moxiflixacin based triple therapy.
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spelling pubmed-28679702010-05-12 Antimicrobial resistance of H. pylori to the outcome of 10-days vs. 7-days Moxifloxacin based therapy for the eradication: a randomized controlled trial Bago, Josip Majstorović, Karolina Belošić-Halle, Željka Kućišec, Nastja Bakula, Vinko Tomić, Monika Bago, Petra Troskot, Rosana Ann Clin Microbiol Antimicrob Research INTRODUCTION: Antibiotic resistance decreases success of Helicobacter pylori (Hp) eradication. Recently published results show low rate of resistance and better compliance with moxifloxacin based regiments. AIMS&METHODS: Whether 7 days moxifloxacin with lansoprasole and amoxycillin can be compared with 10 days moxifloxacin with lansoprasole and amoxycillin according to moxifloxacin resistance. Patients with non-ulcer dyspepsia who had culture and histology positive Hp infection (n = 150) were randomly assigned into two groups. The first group (n = 75) received moxifloxacin 400 mg/d during 7 days and the other (n = 75) received moxifloxacin 400 mg/d during 10 days. All patients received amoxycillin 1 g twice daily, lansoprasole 30 mg twice daily. All Hp cultures were tested for sensitivity to moxifloxacin. RESULTS: 138 patients (92%) completed the study, 68 in the first group and 70 in the second. Eradication rates were 84% (57/68) and 76% (57/75) in the 7 days moxifloxacin group and 90% and 84% in the second group (63/70, 63/75) according to the PP and ITT analysis; p = n.s. Among 129 patients (86% of study group), 6% of strains were primary resistant to moxifloxacin. Eradication of moxifloxacin sensitive/resistant strains was 98%/66%, p < 0.05 CONCLUSION: According to our results we recommend 7 days moxiflixacin based triple therapy. BioMed Central 2010-04-15 /pmc/articles/PMC2867970/ /pubmed/20398300 http://dx.doi.org/10.1186/1476-0711-9-13 Text en Copyright ©2010 Bago et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Bago, Josip
Majstorović, Karolina
Belošić-Halle, Željka
Kućišec, Nastja
Bakula, Vinko
Tomić, Monika
Bago, Petra
Troskot, Rosana
Antimicrobial resistance of H. pylori to the outcome of 10-days vs. 7-days Moxifloxacin based therapy for the eradication: a randomized controlled trial
title Antimicrobial resistance of H. pylori to the outcome of 10-days vs. 7-days Moxifloxacin based therapy for the eradication: a randomized controlled trial
title_full Antimicrobial resistance of H. pylori to the outcome of 10-days vs. 7-days Moxifloxacin based therapy for the eradication: a randomized controlled trial
title_fullStr Antimicrobial resistance of H. pylori to the outcome of 10-days vs. 7-days Moxifloxacin based therapy for the eradication: a randomized controlled trial
title_full_unstemmed Antimicrobial resistance of H. pylori to the outcome of 10-days vs. 7-days Moxifloxacin based therapy for the eradication: a randomized controlled trial
title_short Antimicrobial resistance of H. pylori to the outcome of 10-days vs. 7-days Moxifloxacin based therapy for the eradication: a randomized controlled trial
title_sort antimicrobial resistance of h. pylori to the outcome of 10-days vs. 7-days moxifloxacin based therapy for the eradication: a randomized controlled trial
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867970/
https://www.ncbi.nlm.nih.gov/pubmed/20398300
http://dx.doi.org/10.1186/1476-0711-9-13
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