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Rapid and Direct Transport of Cell Surface APP to the Lysosome defines a novel selective pathway
BACKGROUND: A central feature of Alzheimer's disease is the cleavage of the amyloid precursor protein (APP) to form beta-amyloid peptide (Aβ) by the β-secretase and γ-secretase enzymes. Although this has been shown to occur after endocytosis of APP from the cell surface, the exact compartments...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868040/ https://www.ncbi.nlm.nih.gov/pubmed/20409323 http://dx.doi.org/10.1186/1756-6606-3-11 |