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Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves
The disposition kinetics of levofloxacin was investigated in six male crossbred calves following single intravenous administration, at a dose of 4 mg/kg body weight, into the jugular vein subsequent to a single intramuscular injection of paracetamol (50 mg/kg). At 1 min after the injection of levofl...
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Formato: | Texto |
Lenguaje: | English |
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The Korean Society of Veterinary Science
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868151/ https://www.ncbi.nlm.nih.gov/pubmed/17993749 http://dx.doi.org/10.4142/jvs.2007.8.4.357 |
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author | Dumka, Vinod K. |
author_facet | Dumka, Vinod K. |
author_sort | Dumka, Vinod K. |
collection | PubMed |
description | The disposition kinetics of levofloxacin was investigated in six male crossbred calves following single intravenous administration, at a dose of 4 mg/kg body weight, into the jugular vein subsequent to a single intramuscular injection of paracetamol (50 mg/kg). At 1 min after the injection of levofloxacin, the concentration of levofloxacin in plasma was 17.2 ± 0.36 µg/ml, which rapidly declined to 6.39 ± 0.16 µg/ml at 10 min. The drug level above the MIC(90) in plasma, was detected for up to 10 h. Levofloxacin was rapidly distributed from blood to the tissue compartment as evidenced by the high values of the distribution coefficient, α (17.3 ± 1.65 /h) and the ratio of K(12)/K(21) (1.83 ± 0.12). The values of AUC and Vd(area) were 12.7 ± 0.12 µg.h/ml and 0.63 ± 0.01 l/kg. The high ratio of the AUC/MIC (126.9 ± 1.18) obtained in this study indicated the excellent antibacterial activity of levofloxacin in calves. The elimination half-life, MRT and total body clearance were 1.38 ± 0.01 h, 1.88 ± 0.01 h and 0.32 ± 0.003 l/kg/h, respectively. Based on the pharmacokinetic parameters, an appropriate intravenous dosage regimen for levofloxacin would be 5 mg/kg repeated at 24 h intervals when prescribed with paracetamol in calves. |
format | Text |
id | pubmed-2868151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | The Korean Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-28681512010-05-13 Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves Dumka, Vinod K. J Vet Sci Original Article The disposition kinetics of levofloxacin was investigated in six male crossbred calves following single intravenous administration, at a dose of 4 mg/kg body weight, into the jugular vein subsequent to a single intramuscular injection of paracetamol (50 mg/kg). At 1 min after the injection of levofloxacin, the concentration of levofloxacin in plasma was 17.2 ± 0.36 µg/ml, which rapidly declined to 6.39 ± 0.16 µg/ml at 10 min. The drug level above the MIC(90) in plasma, was detected for up to 10 h. Levofloxacin was rapidly distributed from blood to the tissue compartment as evidenced by the high values of the distribution coefficient, α (17.3 ± 1.65 /h) and the ratio of K(12)/K(21) (1.83 ± 0.12). The values of AUC and Vd(area) were 12.7 ± 0.12 µg.h/ml and 0.63 ± 0.01 l/kg. The high ratio of the AUC/MIC (126.9 ± 1.18) obtained in this study indicated the excellent antibacterial activity of levofloxacin in calves. The elimination half-life, MRT and total body clearance were 1.38 ± 0.01 h, 1.88 ± 0.01 h and 0.32 ± 0.003 l/kg/h, respectively. Based on the pharmacokinetic parameters, an appropriate intravenous dosage regimen for levofloxacin would be 5 mg/kg repeated at 24 h intervals when prescribed with paracetamol in calves. The Korean Society of Veterinary Science 2007-12 2007-12-31 /pmc/articles/PMC2868151/ /pubmed/17993749 http://dx.doi.org/10.4142/jvs.2007.8.4.357 Text en Copyright © 2007 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Dumka, Vinod K. Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves |
title | Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves |
title_full | Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves |
title_fullStr | Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves |
title_full_unstemmed | Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves |
title_short | Disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves |
title_sort | disposition kinetics and dosage regimen of levofloxacin on concomitant administration with paracetamol in crossbred calves |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868151/ https://www.ncbi.nlm.nih.gov/pubmed/17993749 http://dx.doi.org/10.4142/jvs.2007.8.4.357 |
work_keys_str_mv | AT dumkavinodk dispositionkineticsanddosageregimenoflevofloxacinonconcomitantadministrationwithparacetamolincrossbredcalves |