Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase

Nitric oxide synthase (NOS) enzymes synthesize nitric oxide, a signal for vasodilatation and neurotransmission at low levels, and a defensive cytotoxin at higher levels. The high active-site conservation among all three NOS isozymes hinders the design of selective NOS inhibitors to treat inflammatio...

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Detalles Bibliográficos
Autores principales: Garcin, Elsa D., Arvai, Andrew S., Rosenfeld, Robin J., Kroeger, Matt D., Crane, Brian R., Andersson, Gunilla, Andrews, Glen, Hamley, Peter J., Mallinder, Philip R., Nicholls, David J., St-Gallay, Stephen A., Tinker, Alan C., Gensmantel, Nigel P., Mete, Antonio, Cheshire, David R., Connolly, Stephen, Stuehr, Dennis J., Åberg, Anders, Wallace, Alan V., Tainer, John A., Getzoff, Elizabeth D.
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868503/
https://www.ncbi.nlm.nih.gov/pubmed/18849972
http://dx.doi.org/10.1038/nchembio.115

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