Comparative Quantitative Mass Spectrometry Analysis of MHC Class II-Associated Peptides Reveals a Role of GILT in Formation of Self-Peptide Repertoire

Gamma interferon Inducible Lysosomal Thiol reductase (GILT) is a unique lysosomal reductase that reduces disulfide bonds of endocytosed proteins. Lack of GILT clearly decreases CD4 T cell-antigen specific responses against some epitopes of antigens containing disulfide bonds, but not to proteins wit...

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Detalles Bibliográficos
Autores principales: Bogunovic, Branka, Srinivasan, Priya, Ueda, Yumi, Tomita, York, Maric, Maja
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868880/
https://www.ncbi.nlm.nih.gov/pubmed/20485683
http://dx.doi.org/10.1371/journal.pone.0010599

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