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Depletion of DNMT3A Suppressed Cell Proliferation and Restored PTEN in Hepatocellular Carcinoma Cell

Promoter hypermethylation mediated by DNA methyltransferases (DNMTs) is the main reason for epigenetic inactivation of tumor suppressor genes (TSGs). Previous studies showed that DNMT1 and DNMT3B play an important role in CpG island methylation in tumorigenesis. Little is known about the role of DNM...

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Detalles Bibliográficos
Autores principales:	Zhao, Zhujiang, Wu, Qingxiang, Cheng, Jian, Qiu, Xuemei, Zhang, Jianqiong, Fan, Hong
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868982/ https://www.ncbi.nlm.nih.gov/pubmed/20467490 http://dx.doi.org/10.1155/2010/737535

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