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An innovative approach for migraine prevention in young age: a preliminary study

Headache is one of the commonest conditions to affect children and adolescents in industrialized countries. Effective pharmacological treatments without side effects are still lacking. Ginkgolide B, an herbal constituent extract from ginkgo biloba tree leaves, is a natural antiplatelet activating fa...

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Detalles Bibliográficos
Autores principales: Usai, Susanna, Grazzi, Licia, Andrasik, Frank, Bussone, Gennaro
Formato: Texto
Lenguaje:English
Publicado: Springer Milan 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869015/
https://www.ncbi.nlm.nih.gov/pubmed/20464618
http://dx.doi.org/10.1007/s10072-010-0321-6
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author Usai, Susanna
Grazzi, Licia
Andrasik, Frank
Bussone, Gennaro
author_facet Usai, Susanna
Grazzi, Licia
Andrasik, Frank
Bussone, Gennaro
author_sort Usai, Susanna
collection PubMed
description Headache is one of the commonest conditions to affect children and adolescents in industrialized countries. Effective pharmacological treatments without side effects are still lacking. Ginkgolide B, an herbal constituent extract from ginkgo biloba tree leaves, is a natural antiplatelet activating factor (PAF). PAF is a potent proinflammatory and nociceptive agent released during the inflammation process. Therefore, Ginkgolide B can be considered a promising non-pharmacological tool for treatment of migraine with and without aura. We propose to determine the efficacy of Ginkgolide B as preventive treatment in a group of young patients suffering from migraine without aura. A small sample of 24 young patients suffering from migraine without aura entered the open-label prospective trial. Migraine without aura was diagnosed according to International Headache Society criteria. The treatment was well tolerated and the compliance was good. These preliminary data show that Ginkgolide B seems to be effective as preventive treatment in reducing migraine attack frequency and in attenuating the use of symptomatic medication in our small series of children with primary headache.
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spelling pubmed-28690152010-05-24 An innovative approach for migraine prevention in young age: a preliminary study Usai, Susanna Grazzi, Licia Andrasik, Frank Bussone, Gennaro Neurol Sci Oral Communication Headache is one of the commonest conditions to affect children and adolescents in industrialized countries. Effective pharmacological treatments without side effects are still lacking. Ginkgolide B, an herbal constituent extract from ginkgo biloba tree leaves, is a natural antiplatelet activating factor (PAF). PAF is a potent proinflammatory and nociceptive agent released during the inflammation process. Therefore, Ginkgolide B can be considered a promising non-pharmacological tool for treatment of migraine with and without aura. We propose to determine the efficacy of Ginkgolide B as preventive treatment in a group of young patients suffering from migraine without aura. A small sample of 24 young patients suffering from migraine without aura entered the open-label prospective trial. Migraine without aura was diagnosed according to International Headache Society criteria. The treatment was well tolerated and the compliance was good. These preliminary data show that Ginkgolide B seems to be effective as preventive treatment in reducing migraine attack frequency and in attenuating the use of symptomatic medication in our small series of children with primary headache. Springer Milan 2010-05-13 2010 /pmc/articles/PMC2869015/ /pubmed/20464618 http://dx.doi.org/10.1007/s10072-010-0321-6 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Oral Communication
Usai, Susanna
Grazzi, Licia
Andrasik, Frank
Bussone, Gennaro
An innovative approach for migraine prevention in young age: a preliminary study
title An innovative approach for migraine prevention in young age: a preliminary study
title_full An innovative approach for migraine prevention in young age: a preliminary study
title_fullStr An innovative approach for migraine prevention in young age: a preliminary study
title_full_unstemmed An innovative approach for migraine prevention in young age: a preliminary study
title_short An innovative approach for migraine prevention in young age: a preliminary study
title_sort innovative approach for migraine prevention in young age: a preliminary study
topic Oral Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869015/
https://www.ncbi.nlm.nih.gov/pubmed/20464618
http://dx.doi.org/10.1007/s10072-010-0321-6
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