Characteristics of Lipo-Oligosaccharide Loci of Campylobacter jejuni Isolates Associated with Guillain-Barré Syndrome from Hebei, China

Ganglioside mimicry by C.jejuni lipo-oligosaccharides (LOS) could induce the production of autoantibodies against gangliosides and the development of Guillain-Barré syndrome (GBS). The LOS biosynthesis region exhibits significant variation with different strains. Using PCR amplifications of genes fr...

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Autores principales: Jiang, Hai, Zhang, Mao-Jun, Liu, Rui-Chun, Tian, Xin-Ying, Gu, Yi-Xin, Zhang, Jian-Zhong
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869223/
https://www.ncbi.nlm.nih.gov/pubmed/20480006
http://dx.doi.org/10.3390/ijms11031155
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author Jiang, Hai
Zhang, Mao-Jun
Liu, Rui-Chun
Tian, Xin-Ying
Gu, Yi-Xin
Zhang, Jian-Zhong
author_facet Jiang, Hai
Zhang, Mao-Jun
Liu, Rui-Chun
Tian, Xin-Ying
Gu, Yi-Xin
Zhang, Jian-Zhong
author_sort Jiang, Hai
collection PubMed
description Ganglioside mimicry by C.jejuni lipo-oligosaccharides (LOS) could induce the production of autoantibodies against gangliosides and the development of Guillain-Barré syndrome (GBS). The LOS biosynthesis region exhibits significant variation with different strains. Using PCR amplifications of genes from published LOS loci and sequencing the LOS biosynthesis loci, the eight GBS-associated C. jejuni strains from HeBei could be classified into four classes. The expression of sialylated LOS structures (class A) or non-sialylated LOS structures(class F, H and P) in the C. jejuni LOS is considered to be two different factors for the induction of GBS.
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spelling pubmed-28692232010-05-17 Characteristics of Lipo-Oligosaccharide Loci of Campylobacter jejuni Isolates Associated with Guillain-Barré Syndrome from Hebei, China Jiang, Hai Zhang, Mao-Jun Liu, Rui-Chun Tian, Xin-Ying Gu, Yi-Xin Zhang, Jian-Zhong Int J Mol Sci Article Ganglioside mimicry by C.jejuni lipo-oligosaccharides (LOS) could induce the production of autoantibodies against gangliosides and the development of Guillain-Barré syndrome (GBS). The LOS biosynthesis region exhibits significant variation with different strains. Using PCR amplifications of genes from published LOS loci and sequencing the LOS biosynthesis loci, the eight GBS-associated C. jejuni strains from HeBei could be classified into four classes. The expression of sialylated LOS structures (class A) or non-sialylated LOS structures(class F, H and P) in the C. jejuni LOS is considered to be two different factors for the induction of GBS. Molecular Diversity Preservation International (MDPI) 2010-03-19 /pmc/articles/PMC2869223/ /pubmed/20480006 http://dx.doi.org/10.3390/ijms11031155 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Jiang, Hai
Zhang, Mao-Jun
Liu, Rui-Chun
Tian, Xin-Ying
Gu, Yi-Xin
Zhang, Jian-Zhong
Characteristics of Lipo-Oligosaccharide Loci of Campylobacter jejuni Isolates Associated with Guillain-Barré Syndrome from Hebei, China
title Characteristics of Lipo-Oligosaccharide Loci of Campylobacter jejuni Isolates Associated with Guillain-Barré Syndrome from Hebei, China
title_full Characteristics of Lipo-Oligosaccharide Loci of Campylobacter jejuni Isolates Associated with Guillain-Barré Syndrome from Hebei, China
title_fullStr Characteristics of Lipo-Oligosaccharide Loci of Campylobacter jejuni Isolates Associated with Guillain-Barré Syndrome from Hebei, China
title_full_unstemmed Characteristics of Lipo-Oligosaccharide Loci of Campylobacter jejuni Isolates Associated with Guillain-Barré Syndrome from Hebei, China
title_short Characteristics of Lipo-Oligosaccharide Loci of Campylobacter jejuni Isolates Associated with Guillain-Barré Syndrome from Hebei, China
title_sort characteristics of lipo-oligosaccharide loci of campylobacter jejuni isolates associated with guillain-barré syndrome from hebei, china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869223/
https://www.ncbi.nlm.nih.gov/pubmed/20480006
http://dx.doi.org/10.3390/ijms11031155
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