Mathematical Modelling of DNA Replication Reveals a Trade-off between Coherence of Origin Activation and Robustness against Rereplication

Eukaryotic genomes are duplicated from multiple replication origins exactly once per cell cycle. In Saccharomyces cerevisiae, a complex molecular network has been identified that governs the assembly of the replication machinery. Here we develop a mathematical model that links the dynamics of this n...

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Detalles Bibliográficos
Autores principales: Brümmer, Anneke, Salazar, Carlos, Zinzalla, Vittoria, Alberghina, Lilia, Höfer, Thomas
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869307/
https://www.ncbi.nlm.nih.gov/pubmed/20485558
http://dx.doi.org/10.1371/journal.pcbi.1000783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869307/
https://www.ncbi.nlm.nih.gov/pubmed/20485558
http://dx.doi.org/10.1371/journal.pcbi.1000783

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