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Bordetella Adenylate Cyclase Toxin Mobilizes Its β(2) Integrin Receptor into Lipid Rafts to Accomplish Translocation across Target Cell Membrane in Two Steps

Bordetella adenylate cyclase toxin (CyaA) binds the α(M)β(2) integrin (CD11b/CD18, Mac-1, or CR3) of myeloid phagocytes and delivers into their cytosol an adenylate cyclase (AC) enzyme that converts ATP into the key signaling molecule cAMP. We show that penetration of the AC domain across cell membr...

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Detalles Bibliográficos
Autores principales:	Bumba, Ladislav, Masin, Jiri, Fiser, Radovan, Sebo, Peter
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869314/ https://www.ncbi.nlm.nih.gov/pubmed/20485565 http://dx.doi.org/10.1371/journal.ppat.1000901

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