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Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum

Mutant forms of the Plasmodium falciparum transporter PfCRT constitute the key determinant of parasite resistance to chloroquine (CQ), the former first-line antimalarial, and are ubiquitous to infections that fail CQ treatment. However, treatment can often be successful in individuals harboring muta...

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Detalles Bibliográficos
Autores principales:	Valderramos, Stephanie G., Valderramos, Juan-Carlos, Musset, Lise, Purcell, Lisa A., Mercereau-Puijalon, Odile, Legrand, Eric, Fidock, David A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869323/ https://www.ncbi.nlm.nih.gov/pubmed/20485514 http://dx.doi.org/10.1371/journal.ppat.1000887

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